FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200428837> ?p ?o ?g. }

• W3200428837 endingPage "1824" @default.
• W3200428837 startingPage "1818" @default.
• W3200428837 abstract "Hypertrophic cardiomyopathy (HCM) is often caused by pathogenic variants in sarcomeric genes and characterized by left ventricular (LV) hypertrophy, myocardial fibrosis and increased risk of heart failure and arrhythmias. There are no existing therapies to modify disease progression. In this study, we conducted a multi-center, double-blind, placebo-controlled phase 2 clinical trial to assess the safety and efficacy of the angiotensin II receptor blocker valsartan in attenuating disease evolution in early HCM. In total, 178 participants with early-stage sarcomeric HCM were randomized (1:1) to receive valsartan (320 mg daily in adults; 80-160 mg daily in children) or placebo for 2 years ( NCT01912534 ). Standardized changes from baseline to year 2 in LV wall thickness, mass and volumes; left atrial volume; tissue Doppler diastolic and systolic velocities; and serum levels of high-sensitivity troponin T and N-terminal pro-B-type natriuretic protein were integrated into a single composite z-score as the primary outcome. Valsartan (n = 88) improved cardiac structure and function compared to placebo (n = 90), as reflected by an increase in the composite z-score (between-group difference +0.231, 95% confidence interval (+0.098, +0.364); P = 0.001), which met the primary endpoint of the study. Treatment was well-tolerated. These results indicate a key opportunity to attenuate disease progression in early-stage sarcomeric HCM with an accessible and safe medication." @default.
• W3200428837 created "2021-09-27" @default.
• W3200428837 creator A5000020632 @default.
• W3200428837 creator A5002571021 @default.
• W3200428837 creator A5003497085 @default.
• W3200428837 creator A5005091829 @default.
• W3200428837 creator A5006437858 @default.
• W3200428837 creator A5014930870 @default.
• W3200428837 creator A5015754091 @default.
• W3200428837 creator A5031349773 @default.
• W3200428837 creator A5032544285 @default.
• W3200428837 creator A5033742702 @default.
• W3200428837 creator A5038914998 @default.
• W3200428837 creator A5039107780 @default.
• W3200428837 creator A5042926181 @default.
• W3200428837 creator A5045016557 @default.
• W3200428837 creator A5048450888 @default.
• W3200428837 creator A5048994939 @default.
• W3200428837 creator A5051619491 @default.
• W3200428837 creator A5052568194 @default.
• W3200428837 creator A5052863636 @default.
• W3200428837 creator A5053510600 @default.
• W3200428837 creator A5053847300 @default.
• W3200428837 creator A5054197629 @default.
• W3200428837 creator A5054830306 @default.
• W3200428837 creator A5058712786 @default.
• W3200428837 creator A5059264106 @default.
• W3200428837 creator A5060885834 @default.
• W3200428837 creator A5065796273 @default.
• W3200428837 creator A5066041440 @default.
• W3200428837 creator A5067654253 @default.
• W3200428837 creator A5076012103 @default.
• W3200428837 creator A5076205303 @default.
• W3200428837 creator A5080840894 @default.
• W3200428837 creator A5083767342 @default.
• W3200428837 creator A5084813462 @default.
• W3200428837 creator A5086539519 @default.
• W3200428837 date "2021-09-23" @default.
• W3200428837 modified "2023-10-17" @default.
• W3200428837 title "Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial" @default.
• W3200428837 cites W1826116083 @default.
• W3200428837 cites W1966978470 @default.
• W3200428837 cites W1978284123 @default.
• W3200428837 cites W1978660097 @default.
• W3200428837 cites W2019476174 @default.
• W3200428837 cites W2036779262 @default.
• W3200428837 cites W2038198688 @default.
• W3200428837 cites W2051978340 @default.
• W3200428837 cites W2100906399 @default.
• W3200428837 cites W2128077735 @default.
• W3200428837 cites W2145794294 @default.
• W3200428837 cites W2147922516 @default.
• W3200428837 cites W2152350731 @default.
• W3200428837 cites W2158480686 @default.
• W3200428837 cites W2174602966 @default.
• W3200428837 cites W2219899519 @default.
• W3200428837 cites W2510819727 @default.
• W3200428837 cites W2588396622 @default.
• W3200428837 cites W2591736262 @default.
• W3200428837 cites W2978515721 @default.
• W3200428837 cites W2992779961 @default.
• W3200428837 cites W4240337538 @default.
• W3200428837 doi "https://doi.org/10.1038/s41591-021-01505-4" @default.
• W3200428837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34556856" @default.
• W3200428837 hasPublicationYear "2021" @default.
• W3200428837 type Work @default.
• W3200428837 sameAs 3200428837 @default.
• W3200428837 citedByCount "41" @default.
• W3200428837 countsByYear W32004288372021 @default.
• W3200428837 countsByYear W32004288372022 @default.
• W3200428837 countsByYear W32004288372023 @default.
• W3200428837 crossrefType "journal-article" @default.
• W3200428837 hasAuthorship W3200428837A5000020632 @default.
• W3200428837 hasAuthorship W3200428837A5002571021 @default.
• W3200428837 hasAuthorship W3200428837A5003497085 @default.
• W3200428837 hasAuthorship W3200428837A5005091829 @default.
• W3200428837 hasAuthorship W3200428837A5006437858 @default.
• W3200428837 hasAuthorship W3200428837A5014930870 @default.
• W3200428837 hasAuthorship W3200428837A5015754091 @default.
• W3200428837 hasAuthorship W3200428837A5031349773 @default.
• W3200428837 hasAuthorship W3200428837A5032544285 @default.
• W3200428837 hasAuthorship W3200428837A5033742702 @default.
• W3200428837 hasAuthorship W3200428837A5038914998 @default.
• W3200428837 hasAuthorship W3200428837A5039107780 @default.
• W3200428837 hasAuthorship W3200428837A5042926181 @default.
• W3200428837 hasAuthorship W3200428837A5045016557 @default.
• W3200428837 hasAuthorship W3200428837A5048450888 @default.
• W3200428837 hasAuthorship W3200428837A5048994939 @default.
• W3200428837 hasAuthorship W3200428837A5051619491 @default.
• W3200428837 hasAuthorship W3200428837A5052568194 @default.
• W3200428837 hasAuthorship W3200428837A5052863636 @default.
• W3200428837 hasAuthorship W3200428837A5053510600 @default.
• W3200428837 hasAuthorship W3200428837A5053847300 @default.
• W3200428837 hasAuthorship W3200428837A5054197629 @default.
• W3200428837 hasAuthorship W3200428837A5054830306 @default.
• W3200428837 hasAuthorship W3200428837A5058712786 @default.
• W3200428837 hasAuthorship W3200428837A5059264106 @default.
• W3200428837 hasAuthorship W3200428837A5060885834 @default.

• next