FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200433819> ?p ?o ?g. }

• W3200433819 abstract "Summary Transcriptional deregulation is a common feature of many cancers, which is often accompanied by changes in epigenetic controls. These findings have led to the development of therapeutic agents aimed at broad modulation and reprogramming of transcription in a variety of cancers. Histone Deacetylase 3, HDAC3, is one of the main targets of HDAC inhibitors currently in clinical development as cancer therapies, yet the in vivo role of HDAC3 in solid tumors is unknown. Here, we define the role of HDAC3 in two genetic engineered models of the most common subtypes of Kras-driven Non-Small Cell Lung Cancer (NSCLC), Kras G12D , STK11 −/− (KL) and Kras G12D , p53 −/− (KP), where we found that HDAC3 is strongly required for tumor growth of both genotypes in vivo . Transcriptional profiling and mechanistic studies revealed that HDAC3 represses p65 NF-κB-mediated induction of the Senescence Associated Secretory Program (SASP) and HDAC3 binds directly at the promoters of SASP CXC chemokines. Additionally, HDAC3 was found to cooperate with the lung cancer lineage transcription factor NKX2-1 to mediate expression of a common set of target genes. Leveraging observations about one HDAC3/NKX2-1 common target, FGFR1, we identified that an HDAC3-dependent transcriptional cassette becomes hyperactivated as Kras mutant cancer cells develop resistance to the MEK inhibitor Trametinib, and this can be rescued by treatment with the Class I HDAC inhibitor Entinostat. These unexpected findings reveal new roles for HDAC3 in proliferation control in tumors in vivo and identify specific therapeutic contexts for the utilization of HDAC3 inhibitors, whose ability to mechanistically induce SASP may be harnessed therapeutically." @default.
• W3200433819 created "2021-09-27" @default.
• W3200433819 creator A5000138343 @default.
• W3200433819 creator A5006400443 @default.
• W3200433819 creator A5008144881 @default.
• W3200433819 creator A5008943388 @default.
• W3200433819 creator A5028713689 @default.
• W3200433819 creator A5061151936 @default.
• W3200433819 creator A5061704840 @default.
• W3200433819 date "2020-10-14" @default.
• W3200433819 modified "2023-09-27" @default.
• W3200433819 title "HDAC3 regulates senescence and lineage specificity in non-small cell lung cancer" @default.
• W3200433819 cites W1970595265 @default.
• W3200433819 cites W1978527149 @default.
• W3200433819 cites W2002583780 @default.
• W3200433819 cites W2014487118 @default.
• W3200433819 cites W2014677321 @default.
• W3200433819 cites W2027146979 @default.
• W3200433819 cites W2035208208 @default.
• W3200433819 cites W2051549807 @default.
• W3200433819 cites W2057460011 @default.
• W3200433819 cites W2060833045 @default.
• W3200433819 cites W2061765285 @default.
• W3200433819 cites W2079003739 @default.
• W3200433819 cites W2083855694 @default.
• W3200433819 cites W2101450524 @default.
• W3200433819 cites W2104091091 @default.
• W3200433819 cites W2114843025 @default.
• W3200433819 cites W2115593774 @default.
• W3200433819 cites W2116437342 @default.
• W3200433819 cites W2116716449 @default.
• W3200433819 cites W2122914905 @default.
• W3200433819 cites W2125751034 @default.
• W3200433819 cites W2135617839 @default.
• W3200433819 cites W2138428661 @default.
• W3200433819 cites W2140204965 @default.
• W3200433819 cites W2143218205 @default.
• W3200433819 cites W2146040216 @default.
• W3200433819 cites W2149370967 @default.
• W3200433819 cites W2149441684 @default.
• W3200433819 cites W2153562609 @default.
• W3200433819 cites W2159686118 @default.
• W3200433819 cites W2169456326 @default.
• W3200433819 cites W2276640786 @default.
• W3200433819 cites W2283559404 @default.
• W3200433819 cites W2342055991 @default.
• W3200433819 cites W2474854223 @default.
• W3200433819 cites W2522492952 @default.
• W3200433819 cites W2566497735 @default.
• W3200433819 cites W2586373162 @default.
• W3200433819 cites W2595713273 @default.
• W3200433819 cites W2606377102 @default.
• W3200433819 cites W2627082476 @default.
• W3200433819 cites W2758304764 @default.
• W3200433819 cites W2774935716 @default.
• W3200433819 cites W2895908547 @default.
• W3200433819 cites W2898692674 @default.
• W3200433819 cites W2899560692 @default.
• W3200433819 cites W2914204349 @default.
• W3200433819 cites W2951548994 @default.
• W3200433819 cites W2966596554 @default.
• W3200433819 cites W2975888204 @default.
• W3200433819 cites W2981582302 @default.
• W3200433819 cites W3006996572 @default.
• W3200433819 cites W3014162795 @default.
• W3200433819 cites W3047311641 @default.
• W3200433819 doi "https://doi.org/10.1101/2020.10.14.338590" @default.
• W3200433819 hasPublicationYear "2020" @default.
• W3200433819 type Work @default.
• W3200433819 sameAs 3200433819 @default.
• W3200433819 citedByCount "4" @default.
• W3200433819 countsByYear W32004338192021 @default.
• W3200433819 countsByYear W32004338192022 @default.
• W3200433819 countsByYear W32004338192023 @default.
• W3200433819 crossrefType "posted-content" @default.
• W3200433819 hasAuthorship W3200433819A5000138343 @default.
• W3200433819 hasAuthorship W3200433819A5006400443 @default.
• W3200433819 hasAuthorship W3200433819A5008144881 @default.
• W3200433819 hasAuthorship W3200433819A5008943388 @default.
• W3200433819 hasAuthorship W3200433819A5028713689 @default.
• W3200433819 hasAuthorship W3200433819A5061151936 @default.
• W3200433819 hasAuthorship W3200433819A5061704840 @default.
• W3200433819 hasBestOaLocation W32004338191 @default.
• W3200433819 hasConcept C104317684 @default.
• W3200433819 hasConcept C121608353 @default.
• W3200433819 hasConcept C13721689 @default.
• W3200433819 hasConcept C2778305200 @default.
• W3200433819 hasConcept C2781187634 @default.
• W3200433819 hasConcept C41091548 @default.
• W3200433819 hasConcept C502942594 @default.
• W3200433819 hasConcept C526805850 @default.
• W3200433819 hasConcept C54355233 @default.
• W3200433819 hasConcept C64927066 @default.
• W3200433819 hasConcept C85240754 @default.
• W3200433819 hasConcept C86339819 @default.
• W3200433819 hasConcept C86803240 @default.
• W3200433819 hasConceptScore W3200433819C104317684 @default.
• W3200433819 hasConceptScore W3200433819C121608353 @default.
• W3200433819 hasConceptScore W3200433819C13721689 @default.
• W3200433819 hasConceptScore W3200433819C2778305200 @default.

• next