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• W3200434989 abstract "Abstract The central nervous system (CNS) antigen presenting cell (APC) which primes anti-tumor CD8 + T cell responses remains undefined. Elsewhere, the conventional dendritic cell 1 (cDC1) performs this role. However, steady-state brain cDC1 are rare; cDC localize to choroid plexus and dura. Using preclinical glioblastoma models and cDC1-deficient mice, we explored the role of cDC1 in CNS anti-tumor immunity. We determined that cDC1 mediate checkpoint blockade-induced survival benefit and prime neoantigen-specific CD8 + T cells against brain tumors. We observed that cDC, including cDC1, isolated from the tumor, the dura, and the CNS-draining cervical lymph nodes harbored a traceable fluorescent tumor-antigen. In patient samples, we observed several APC subsets (including the CD141 + cDC1-equivalent) infiltrating glioblastomas, meningiomas, and dura. In these same subsets, we identified a tumor-specific fluorescent metabolite of 5- aminolevulinic acid, which labels tumor cells during fluorescence-guided glioblastoma resection. Together, these data elucidate the specialized behavior of cDC1 and suggest cDC1 play a significant role in CNS anti-tumor immunity. One Sentence Summary CNS cDC1 engage in previously undefined behavior to establish immune responses against brain tumors." @default.
• W3200434989 created "2021-09-27" @default.
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• W3200434989 date "2021-09-15" @default.
• W3200434989 modified "2023-10-18" @default.
• W3200434989 title "The conventional dendritic cell 1 subset primes CD8⁺ T cells and traffics tumor antigen to drive anti-tumor immunity in the brain" @default.
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