Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200436926> ?p ?o ?g. }
- W3200436926 abstract "There is a critical requirement for alternative strategies to provide the better treatment in colorectal cancer (CRC). Hence, our goal was to propose novel biomarkers as well as drug candidates for its treatment through differential interactome based drug repositioning. Differentially interacting proteins and their modules were identified, and their prognostic power were estimated through survival analyses. Drug repositioning was carried out for significant target proteins, and candidate drugs were analyzed via in silico molecular docking prior to in vitro cell viability assays in CRC cell lines. Six modules (mAPEX1, mCCT7, mHSD17B10, mMYC, mPSMB5, mRAN) were highlighted considering their prognostic performance. Drug repositioning resulted in eight drugs (abacavir, ribociclib, exemestane, voriconazole, nortriptyline hydrochloride, theophylline, bromocriptine mesylate, and tolcapone). Moreover, significant in vitro inhibition profiles were obtained in abacavir, nortriptyline hydrochloride, exemestane, tolcapone, and theophylline (positive control). Our findings may provide new and complementary strategies for the treatment of CRC." @default.
- W3200436926 created "2021-09-27" @default.
- W3200436926 creator A5001064957 @default.
- W3200436926 creator A5015132885 @default.
- W3200436926 creator A5021458505 @default.
- W3200436926 creator A5028575098 @default.
- W3200436926 creator A5052824858 @default.
- W3200436926 creator A5058024427 @default.
- W3200436926 creator A5062402093 @default.
- W3200436926 date "2021-09-14" @default.
- W3200436926 modified "2023-10-18" @default.
- W3200436926 title "Differential Interactome Based Drug Repositioning Unraveled Abacavir, Exemestane, Nortriptyline Hydrochloride, and Tolcapone as Potential Therapeutics for Colorectal Cancers" @default.
- W3200436926 cites W1600604896 @default.
- W3200436926 cites W1843054844 @default.
- W3200436926 cites W1881164779 @default.
- W3200436926 cites W1948396178 @default.
- W3200436926 cites W1968812902 @default.
- W3200436926 cites W1980222592 @default.
- W3200436926 cites W2006043903 @default.
- W3200436926 cites W2012034410 @default.
- W3200436926 cites W2026673536 @default.
- W3200436926 cites W2037915750 @default.
- W3200436926 cites W2047544230 @default.
- W3200436926 cites W2053868632 @default.
- W3200436926 cites W2066503677 @default.
- W3200436926 cites W2076556632 @default.
- W3200436926 cites W2088632292 @default.
- W3200436926 cites W2098585343 @default.
- W3200436926 cites W2103017472 @default.
- W3200436926 cites W2108664016 @default.
- W3200436926 cites W2115858100 @default.
- W3200436926 cites W2118258530 @default.
- W3200436926 cites W2121604817 @default.
- W3200436926 cites W2123832119 @default.
- W3200436926 cites W2128447158 @default.
- W3200436926 cites W2131012373 @default.
- W3200436926 cites W2134967712 @default.
- W3200436926 cites W2135056923 @default.
- W3200436926 cites W2146303969 @default.
- W3200436926 cites W2150420891 @default.
- W3200436926 cites W2153768000 @default.
- W3200436926 cites W2157230165 @default.
- W3200436926 cites W2159675211 @default.
- W3200436926 cites W2165061736 @default.
- W3200436926 cites W2170146596 @default.
- W3200436926 cites W2174011260 @default.
- W3200436926 cites W2329659234 @default.
- W3200436926 cites W2346066981 @default.
- W3200436926 cites W2474747771 @default.
- W3200436926 cites W2490441649 @default.
- W3200436926 cites W2559588208 @default.
- W3200436926 cites W2588541827 @default.
- W3200436926 cites W2594844287 @default.
- W3200436926 cites W2607277585 @default.
- W3200436926 cites W2733963632 @default.
- W3200436926 cites W2765222180 @default.
- W3200436926 cites W2782721143 @default.
- W3200436926 cites W2794096415 @default.
- W3200436926 cites W2794858862 @default.
- W3200436926 cites W2800595743 @default.
- W3200436926 cites W2806421539 @default.
- W3200436926 cites W2884450790 @default.
- W3200436926 cites W2887766329 @default.
- W3200436926 cites W2897184001 @default.
- W3200436926 cites W2899070097 @default.
- W3200436926 cites W2914243753 @default.
- W3200436926 cites W2914885890 @default.
- W3200436926 cites W2915536738 @default.
- W3200436926 cites W2941187122 @default.
- W3200436926 cites W2944423813 @default.
- W3200436926 cites W2951510590 @default.
- W3200436926 cites W2957032355 @default.
- W3200436926 cites W2976893606 @default.
- W3200436926 cites W2981792677 @default.
- W3200436926 cites W2983323103 @default.
- W3200436926 cites W3007998232 @default.
- W3200436926 cites W3014325871 @default.
- W3200436926 cites W3016582969 @default.
- W3200436926 cites W3021105989 @default.
- W3200436926 cites W3034010729 @default.
- W3200436926 cites W3089266616 @default.
- W3200436926 cites W3125665293 @default.
- W3200436926 cites W3128646645 @default.
- W3200436926 cites W3131345330 @default.
- W3200436926 cites W4242404314 @default.
- W3200436926 cites W2605986008 @default.
- W3200436926 doi "https://doi.org/10.3389/fbinf.2021.710591" @default.
- W3200436926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36303724" @default.
- W3200436926 hasPublicationYear "2021" @default.
- W3200436926 type Work @default.
- W3200436926 sameAs 3200436926 @default.
- W3200436926 citedByCount "1" @default.
- W3200436926 countsByYear W32004369262021 @default.
- W3200436926 crossrefType "journal-article" @default.
- W3200436926 hasAuthorship W3200436926A5001064957 @default.
- W3200436926 hasAuthorship W3200436926A5015132885 @default.
- W3200436926 hasAuthorship W3200436926A5021458505 @default.
- W3200436926 hasAuthorship W3200436926A5028575098 @default.
- W3200436926 hasAuthorship W3200436926A5052824858 @default.
- W3200436926 hasAuthorship W3200436926A5058024427 @default.