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- W3200451490 endingPage "10431" @default.
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- W3200451490 abstract "Divalent calcium ion (Ca2+) plays an indispensable role as a second messenger in a myriad of signal transduction processes. Of utmost importance for the faultless functioning of calcium-modulated signaling proteins is their binding selectivity of the native metal cation over rival biogenic/abiogenic metal ion contenders in the intra/extracellular fluids. In this Perspective, we summarize recent findings on the competition between the cognate Ca2+ and other biogenic or abiogenic divalent cations for binding to Ca2+-signaling proteins or organic cofactors. We describe the competition between the two most abundant intracellular biogenic metal ions (Mg2+ and Ca2+) for Ca2+-binding sites in signaling proteins, followed by the rivalry between native Ca2+ and therapeutic Li+ as well as toxic Pb2+. We delineate the key factors governing the rivalry between the native and non-native cations in proteins and highlight key implications for the biological performance of the respective proteins/organic cofactors." @default.
- W3200451490 created "2021-09-27" @default.
- W3200451490 creator A5010018908 @default.
- W3200451490 creator A5045806392 @default.
- W3200451490 creator A5087782606 @default.
- W3200451490 date "2021-09-13" @default.
- W3200451490 modified "2023-09-25" @default.
- W3200451490 title "Calcium in Signaling: Its Specificity and Vulnerabilities toward Biogenic and Abiogenic Metal Ions" @default.
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