FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200452118> ?p ?o ?g. }

• W3200452118 abstract "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has triggered an unprecedented international effort to sequence complete viral genomes. We leveraged this wealth of information to characterize the substitution spectrum of SARS-CoV-2 and to compare it with those of other human and animal coronaviruses. We show that, once nucleotide composition is taken into account, human and most animal coronaviruses display a mutation spectrum dominated by C to U and G to U substitutions, a feature that is not shared by other positive-sense RNA viruses. However, the proportions of C to U and G to U substitutions tend to decrease as divergence increases, suggesting that, whatever their origin, a proportion of these changes is subsequently eliminated by purifying selection. Analysis of the sequence context of C to U substitutions showed little evidence of apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC)-mediated editing and such contexts were similar for SARS-CoV-2 and Middle East respiratory syndrome coronavirus sampled from different hosts, despite different repertoires of APOBEC3 proteins in distinct species. Conversely, we found evidence that C to U and G to U changes affect CpG dinucleotides at a frequency higher than expected. Whereas this suggests ongoing selective reduction of CpGs, this effect alone cannot account for the substitution spectra. Finally, we show that, during the first months of SARS-CoV-2 pandemic spread, the frequency of both G to U and C to U substitutions increased. Our data suggest that the substitution spectrum of SARS-CoV-2 is determined by an interplay of factors, including intrinsic biases of the replication process, avoidance of CpG dinucleotides and other constraints exerted by the new host." @default.
• W3200452118 created "2021-09-27" @default.
• W3200452118 creator A5007813132 @default.
• W3200452118 creator A5033073054 @default.
• W3200452118 creator A5035231715 @default.
• W3200452118 creator A5053291807 @default.
• W3200452118 creator A5069534962 @default.
• W3200452118 date "2021-09-13" @default.
• W3200452118 modified "2023-09-26" @default.
• W3200452118 title "The substitution spectra of coronavirus genomes" @default.
• W3200452118 cites W1984259198 @default.
• W3200452118 cites W1994542643 @default.
• W3200452118 cites W2000206815 @default.
• W3200452118 cites W2005174749 @default.
• W3200452118 cites W2012294035 @default.
• W3200452118 cites W2017689151 @default.
• W3200452118 cites W2018212701 @default.
• W3200452118 cites W2062254583 @default.
• W3200452118 cites W2064424928 @default.
• W3200452118 cites W2069752975 @default.
• W3200452118 cites W2084241014 @default.
• W3200452118 cites W2084733358 @default.
• W3200452118 cites W2099743715 @default.
• W3200452118 cites W2118903236 @default.
• W3200452118 cites W2126428749 @default.
• W3200452118 cites W2138509994 @default.
• W3200452118 cites W2160378127 @default.
• W3200452118 cites W2227495319 @default.
• W3200452118 cites W2538584349 @default.
• W3200452118 cites W2583527348 @default.
• W3200452118 cites W2759289851 @default.
• W3200452118 cites W2791234962 @default.
• W3200452118 cites W2791457130 @default.
• W3200452118 cites W2797474345 @default.
• W3200452118 cites W2807395067 @default.
• W3200452118 cites W2883251903 @default.
• W3200452118 cites W2903899730 @default.
• W3200452118 cites W2929344305 @default.
• W3200452118 cites W2970236921 @default.
• W3200452118 cites W2971082207 @default.
• W3200452118 cites W2981250203 @default.
• W3200452118 cites W2982379000 @default.
• W3200452118 cites W2986794069 @default.
• W3200452118 cites W2996177842 @default.
• W3200452118 cites W3000834295 @default.
• W3200452118 cites W3013858102 @default.
• W3200452118 cites W3015361654 @default.
• W3200452118 cites W3016489853 @default.
• W3200452118 cites W3020188044 @default.
• W3200452118 cites W3020655115 @default.
• W3200452118 cites W3021283406 @default.
• W3200452118 cites W3025620739 @default.
• W3200452118 cites W3035786310 @default.
• W3200452118 cites W3038661011 @default.
• W3200452118 cites W3039901154 @default.
• W3200452118 cites W3045552416 @default.
• W3200452118 cites W3046141384 @default.
• W3200452118 cites W3048564366 @default.
• W3200452118 cites W3065795114 @default.
• W3200452118 cites W3089734131 @default.
• W3200452118 cites W3092577522 @default.
• W3200452118 cites W3093413235 @default.
• W3200452118 cites W3094288704 @default.
• W3200452118 cites W3096967708 @default.
• W3200452118 cites W3097776377 @default.
• W3200452118 cites W3102258632 @default.
• W3200452118 cites W3115292116 @default.
• W3200452118 cites W3120222018 @default.
• W3200452118 cites W3125070192 @default.
• W3200452118 cites W3127438088 @default.
• W3200452118 cites W3129692419 @default.
• W3200452118 cites W3131820551 @default.
• W3200452118 cites W3135415606 @default.
• W3200452118 cites W3138025113 @default.
• W3200452118 cites W3149586990 @default.
• W3200452118 cites W3153411761 @default.
• W3200452118 cites W3154144457 @default.
• W3200452118 cites W3156343712 @default.
• W3200452118 cites W3157249971 @default.
• W3200452118 cites W3157429391 @default.
• W3200452118 cites W3158098632 @default.
• W3200452118 cites W3161424923 @default.
• W3200452118 cites W763093762 @default.
• W3200452118 doi "https://doi.org/10.1093/bib/bbab382" @default.
• W3200452118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8499949" @default.
• W3200452118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34518866" @default.
• W3200452118 hasPublicationYear "2021" @default.
• W3200452118 type Work @default.
• W3200452118 sameAs 3200452118 @default.
• W3200452118 citedByCount "14" @default.
• W3200452118 countsByYear W32004521182021 @default.
• W3200452118 countsByYear W32004521182022 @default.
• W3200452118 countsByYear W32004521182023 @default.
• W3200452118 crossrefType "journal-article" @default.
• W3200452118 hasAuthorship W3200452118A5007813132 @default.
• W3200452118 hasAuthorship W3200452118A5033073054 @default.
• W3200452118 hasAuthorship W3200452118A5035231715 @default.
• W3200452118 hasAuthorship W3200452118A5053291807 @default.
• W3200452118 hasAuthorship W3200452118A5069534962 @default.
• W3200452118 hasBestOaLocation W32004521181 @default.

• next