FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200463588> ?p ?o ?g. }

• W3200463588 endingPage "2508" @default.
• W3200463588 startingPage "2493" @default.
• W3200463588 abstract "Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection occurring mainly in immunocompromised patients. We recently identified IPA as an emerging co-infection with high mortality in critically ill, but otherwise immunocompetent influenza patients. The neuraminidase inhibitor oseltamivir is the current standard-of-care treatment in hospitalized influenza patients; however, its efficacy in influenza-associated pulmonary aspergillosis (IAPA) is not known. Therefore, we have established an imaging-supported double-hit mouse model to investigate the therapeutic effect of oseltamivir on the development of IAPA. Immunocompetent mice received intranasal instillation influenza A or PBS followed by orotracheal inoculation with Aspergillus fumigatus 4 days later. Oseltamivir treatment or placebo was started at day 0, day 2, or day 4. Daily monitoring included micro-computed tomography and bioluminescence imaging of pneumonia and fungal burden. Non-invasive biomarkers were complemented with imaging, molecular, immunological, and pathological analysis. Influenza virus-infected immunocompetent mice developed proven airway IPA upon co-infection with Aspergillus fumigatus, whereas non-influenza-infected mice fully cleared Aspergillus, confirming influenza as a risk factor for developing IPA. Longitudinal micro-CT showed pulmonary lesions after influenza infection worsening after Aspergillus co-infection, congruent with bioluminescence imaging and histology confirming Aspergillus pneumonia. Early oseltamivir treatment prevented severe influenza pneumonia and mitigated the development of IPA and associated mortality. A time-dependent treatment effect was consistently observed with imaging, molecular, and pathological analyses. Hence, our findings underscore the importance of initiating oseltamivir as soon as possible, to suppress influenza infection and mitigate the risk of potentially lethal IAPA disease." @default.
• W3200463588 created "2021-09-27" @default.
• W3200463588 creator A5010677190 @default.
• W3200463588 creator A5012569782 @default.
• W3200463588 creator A5018942895 @default.
• W3200463588 creator A5022395132 @default.
• W3200463588 creator A5035437774 @default.
• W3200463588 creator A5045221135 @default.
• W3200463588 creator A5055148071 @default.
• W3200463588 creator A5061589261 @default.
• W3200463588 creator A5063224904 @default.
• W3200463588 creator A5074759534 @default.
• W3200463588 creator A5074930464 @default.
• W3200463588 creator A5081640914 @default.
• W3200463588 creator A5085099013 @default.
• W3200463588 creator A5087565405 @default.
• W3200463588 date "2021-09-21" @default.
• W3200463588 modified "2023-10-13" @default.
• W3200463588 title "Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model" @default.
• W3200463588 cites W1553473844 @default.
• W3200463588 cites W1898442347 @default.
• W3200463588 cites W1964250840 @default.
• W3200463588 cites W1996251686 @default.
• W3200463588 cites W2037905325 @default.
• W3200463588 cites W2058218234 @default.
• W3200463588 cites W2063563210 @default.
• W3200463588 cites W2076298858 @default.
• W3200463588 cites W2084445513 @default.
• W3200463588 cites W2090196962 @default.
• W3200463588 cites W2095589751 @default.
• W3200463588 cites W2102263282 @default.
• W3200463588 cites W2106772621 @default.
• W3200463588 cites W2122256368 @default.
• W3200463588 cites W2122352069 @default.
• W3200463588 cites W2145665328 @default.
• W3200463588 cites W2155935143 @default.
• W3200463588 cites W2162695199 @default.
• W3200463588 cites W2166822160 @default.
• W3200463588 cites W2169219994 @default.
• W3200463588 cites W2172047752 @default.
• W3200463588 cites W2256756668 @default.
• W3200463588 cites W2273554450 @default.
• W3200463588 cites W2332711180 @default.
• W3200463588 cites W2471261057 @default.
• W3200463588 cites W2515591485 @default.
• W3200463588 cites W2532311051 @default.
• W3200463588 cites W2605187611 @default.
• W3200463588 cites W2756943820 @default.
• W3200463588 cites W2761858386 @default.
• W3200463588 cites W2791922959 @default.
• W3200463588 cites W2794045287 @default.
• W3200463588 cites W2802058109 @default.
• W3200463588 cites W2886381549 @default.
• W3200463588 cites W2895904645 @default.
• W3200463588 cites W2896178659 @default.
• W3200463588 cites W2901114033 @default.
• W3200463588 cites W2919747284 @default.
• W3200463588 cites W2944413980 @default.
• W3200463588 cites W2947297348 @default.
• W3200463588 cites W2991489244 @default.
• W3200463588 cites W2994983097 @default.
• W3200463588 cites W2996369812 @default.
• W3200463588 cites W3000268018 @default.
• W3200463588 cites W3006418822 @default.
• W3200463588 cites W3033926454 @default.
• W3200463588 cites W3036766665 @default.
• W3200463588 cites W3160544516 @default.
• W3200463588 cites W4229698613 @default.
• W3200463588 doi "https://doi.org/10.1080/21505594.2021.1974327" @default.
• W3200463588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34546839" @default.
• W3200463588 hasPublicationYear "2021" @default.
• W3200463588 type Work @default.
• W3200463588 sameAs 3200463588 @default.
• W3200463588 citedByCount "17" @default.
• W3200463588 countsByYear W32004635882021 @default.
• W3200463588 countsByYear W32004635882022 @default.
• W3200463588 countsByYear W32004635882023 @default.
• W3200463588 crossrefType "journal-article" @default.
• W3200463588 hasAuthorship W3200463588A5010677190 @default.
• W3200463588 hasAuthorship W3200463588A5012569782 @default.
• W3200463588 hasAuthorship W3200463588A5018942895 @default.
• W3200463588 hasAuthorship W3200463588A5022395132 @default.
• W3200463588 hasAuthorship W3200463588A5035437774 @default.
• W3200463588 hasAuthorship W3200463588A5045221135 @default.
• W3200463588 hasAuthorship W3200463588A5055148071 @default.
• W3200463588 hasAuthorship W3200463588A5061589261 @default.
• W3200463588 hasAuthorship W3200463588A5063224904 @default.
• W3200463588 hasAuthorship W3200463588A5074759534 @default.
• W3200463588 hasAuthorship W3200463588A5074930464 @default.
• W3200463588 hasAuthorship W3200463588A5081640914 @default.
• W3200463588 hasAuthorship W3200463588A5085099013 @default.
• W3200463588 hasAuthorship W3200463588A5087565405 @default.
• W3200463588 hasBestOaLocation W32004635881 @default.
• W3200463588 hasConcept C126322002 @default.
• W3200463588 hasConcept C134164806 @default.
• W3200463588 hasConcept C159047783 @default.
• W3200463588 hasConcept C190139176 @default.
• W3200463588 hasConcept C203014093 @default.

• next