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- W3200469478 abstract "Purpose: Capecitabine is an oral fluoropyrimidine used for the treatment of metastatic breast cancer (m-BC) [1]. Its catabolism depends on the enzyme dihydropyrimidine dehydrogenase (DPD). Polymorphic variants in the DPYD gene are associated with partial or complete DPD activity and severe toxicities to fluoropyrimidine therapy [2]. Preliminary work previously carried out in our institution suggested that prospective DPYD genotyping is a cost-effective and predictive biomarker of capecitabine toxicity. The aim of this study was to validate these findings." @default.
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- W3200469478 date "2019-07-01" @default.
- W3200469478 modified "2023-09-27" @default.
- W3200469478 title "Pretreatment DPYD Genotyping Reduces the Risk of Capecitabine-associated Severe Toxicities: a Prospective Validation Study" @default.
- W3200469478 doi "https://doi.org/10.1016/j.clon.2019.03.036" @default.
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