Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200475404> ?p ?o ?g. }
- W3200475404 abstract "Melanoma is the deadliest form of skin cancer. Although targeted therapies and immunotherapies have revolutionized the treatment of metastatic melanoma, most patients are not cured. Therapy resistance remains a significant clinical challenge. Melanoma comprises phenotypically distinct subpopulations of cells, exhibiting distinct gene signatures leading to tumor heterogeneity and favoring therapeutic resistance. Cellular plasticity in melanoma is referred to as phenotype switching. Regardless of their genomic classification, melanomas switch from a proliferative and differentiated phenotype to an invasive, dedifferentiated and often therapy-resistant state. In this review we discuss potential mechanisms underpinning melanoma phenotype switching, how this cellular plasticity contributes to resistance to both targeted therapies and immunotherapies. Finally, we highlight novel strategies to target plasticity and their potential clinical impact in melanoma." @default.
- W3200475404 created "2021-09-27" @default.
- W3200475404 creator A5020543727 @default.
- W3200475404 creator A5039248904 @default.
- W3200475404 creator A5039614060 @default.
- W3200475404 creator A5089111286 @default.
- W3200475404 date "2021-09-16" @default.
- W3200475404 modified "2023-10-18" @default.
- W3200475404 title "Melanoma Plasticity: Promoter of Metastasis and Resistance to Therapy" @default.
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