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- W3200505541 abstract "Minocycline hydrochloride (MH) is a tetracycline derivative antibiotic that also has anti-inflammatory, anti-oxidative, and anti-apoptotic properties. It has demonstrated therapeutic effects in infection, inflammation, tumor, as well as cardiovascular, renal, and neurological disorders due to its anti-microbial, anti-inflammatory, and cytoprotective properties. However, the inability to translate the high doses used in experimental animals to tolerable doses in human patients limits its clinical application. Localized delivery can potentially expose the diseased tissue to high concentrations of MH that systemic delivery cannot achieve, while minimizing the side effects from systemic exposure. However, current drug delivery systems are not ideal for local delivery of bioactive MH for an extended period of time because it is a small molecule drug (MW 494 Da) with high water solubility. In this study, we developed a novel metal ion binding mediated drug delivery mechanism. Based on this mechanism, we developed two drug delivery systems: layer-by-layer (LbL) thin film coatings and self-assembled insoluble complex. In addition, the interaction between MH and dextran sulfate (DS), as well as the factors affecting MH release were studied. Moreover, the complexes can be encapsulated into an injectable agarose hydrogel to be immobilized at the injury site. We also investigated strategies to control MH release from the hydrogel. Furthermore, we investigated using the metal ion-assisted self-assembled complex for controlled and sustained delivery of therapeutic proteins for biomedical applications.%%%%Ph.D., Biomedical Engineering – Drexel University, 2015" @default.
- W3200505541 created "2021-09-27" @default.
- W3200505541 creator A5018465248 @default.
- W3200505541 date "2021-07-16" @default.
- W3200505541 modified "2023-09-26" @default.
- W3200505541 title "Development and characterization of a novel metal ion binding-mediated drug delivery mechanism for biomedical applications" @default.
- W3200505541 doi "https://doi.org/10.17918/etd-7581" @default.
- W3200505541 hasPublicationYear "2021" @default.
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