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- W3200508743 abstract "Observing microscale neurovascular dynamics under different physiological conditions is of great importance to understanding brain functions and disorders. Here, we report a dual-model wearable device and an auxiliary data processing algorithm to derive neurovascular dynamics. The device integrates high-resolution photoacoustic microscopy and electroencephalography (EEG), which allows observing capillary-level hemodynamics and neural activities in anesthesia and freely moving rats. By using the developed algorithm, multiple photoacoustic/EEG parameters extracted and correlated enables investigation of the interplay between neural and vascular activities. We employed this platform to study the neurovascular coupling during different types of seizures in rats under various physiological conditions. We observed cerebral vascular vasodilation/constriction corresponding well to the seizure on/off in rats under regular anesthesia conditions, showing a strong neurovascular coupling coefficient. In rats under weak anesthesia and freely moving conditions, more intense cerebral hemodynamics and neural activities occurred with a weaker neurovascular coupling coefficient. The comprehensively quantitative analyses suggest that anesthesia has a dominant impact on the seizure onset and affect the neurovascular coupling correlation in the current drug-induced localized seizure model. Our study reveals that the designed platform has the potential to support studies on brain functions and disorders in diseased rodent models in various physiological states." @default.
- W3200508743 created "2021-09-27" @default.
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- W3200508743 date "2021-09-30" @default.
- W3200508743 modified "2023-10-15" @default.
- W3200508743 title "Dual-model wearable photoacoustic microscopy and electroencephalograph: study of neurovascular coupling in anesthetized and freely moving rats" @default.
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- W3200508743 doi "https://doi.org/10.1364/boe.438596" @default.
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