FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200512237> ?p ?o ?g. }

• W3200512237 endingPage "1267" @default.
• W3200512237 startingPage "1267" @default.
• W3200512237 abstract "The present study focused on secondary injury following the middle cerebral artery (MCA) occlusion in rats not linked to the MCA’s feeding zone. This entity has been very rarely studied. Additionally, this study investigated the rates of expression of five fundamental angiogenic biomarkers called endoglin, vascular endothelial growth factors-A (VEGF-A), endothelin-1 (ET-1), 2granulocyte colony-stimulating factor (G-CSF), and angiopoietin-using the MCA occlusion (MCAO) model. The random allocation of twelve adult male albino rats was in two groups. As a sham control group, six rats were used. This group was subjected to a sham operation without MCAO. The MCAO group consisted of six rats that were subjected to MCAO operation. After three days, the rats were sacrificed. The cerebellar specimens were immediately processed for light microscopic examination. An angiogenic biomarkers multiplex assay from multiplex was used to assess endoglin levels, VEGF-A, ET-1, angiopoietin-2, and G-CSF in serum samples. Hematoxylin and eosin-stained sections showed that the cerebellar cortex of rats of the MCAO group was more affected than the sham control group. Furthermore, Nissl stain and immunohistochemical analysis revealed an apparent increase in the number of positive immunoreactive in the cerebellar cortex and an evident decrease in Nissl granules in Purkinje cells of the MCAO rats, in contrast to the control rats. In addition, there was a significant increase in angiogenic factors VEGF-A, ET-1, angiopoietin-2, and endoglin. Interestingly, there was an increase in the G-CSF but a non-significant in the MCAO rats compared to the control rats. Furthermore, there was a significant correlation between the angiopoietin-2 and ET-1, and between G-CSF and ET-1. VEGF-A also exhibited significant positive correlations with the G-CSF serum level parameter, Endoglin, and ET-1. Rats subjected to MCAO are a suitable model to study secondary injury away from MCA’s feeding zone. Additionally, valuable insights into the association and interaction between altered angiogenic factors and acute ischemic stroke induced by MCAO in rats." @default.
• W3200512237 created "2021-09-27" @default.
• W3200512237 creator A5040342258 @default.
• W3200512237 date "2021-09-18" @default.
• W3200512237 modified "2023-10-12" @default.
• W3200512237 title "Secondary Cerebellar Cortex Injury in Albino Male Rats after MCAO: A Histological and Biochemical Study" @default.
• W3200512237 cites W1966545752 @default.
• W3200512237 cites W1967182796 @default.
• W3200512237 cites W1968393520 @default.
• W3200512237 cites W1968844777 @default.
• W3200512237 cites W1974323273 @default.
• W3200512237 cites W1974547403 @default.
• W3200512237 cites W1981232919 @default.
• W3200512237 cites W1984690004 @default.
• W3200512237 cites W1991425223 @default.
• W3200512237 cites W1995785702 @default.
• W3200512237 cites W2001500938 @default.
• W3200512237 cites W2008041043 @default.
• W3200512237 cites W2012537607 @default.
• W3200512237 cites W2014648588 @default.
• W3200512237 cites W2021612766 @default.
• W3200512237 cites W2024725915 @default.
• W3200512237 cites W2029503397 @default.
• W3200512237 cites W2030828007 @default.
• W3200512237 cites W2031025093 @default.
• W3200512237 cites W2032065763 @default.
• W3200512237 cites W2035433017 @default.
• W3200512237 cites W2042034876 @default.
• W3200512237 cites W2047272909 @default.
• W3200512237 cites W2051553211 @default.
• W3200512237 cites W2053068006 @default.
• W3200512237 cites W2053977520 @default.
• W3200512237 cites W2054945824 @default.
• W3200512237 cites W2073679412 @default.
• W3200512237 cites W2075965178 @default.
• W3200512237 cites W2076918465 @default.
• W3200512237 cites W2079485368 @default.
• W3200512237 cites W2089136110 @default.
• W3200512237 cites W2102577280 @default.
• W3200512237 cites W2103704226 @default.
• W3200512237 cites W2109503237 @default.
• W3200512237 cites W2112505121 @default.
• W3200512237 cites W2116293168 @default.
• W3200512237 cites W2139444079 @default.
• W3200512237 cites W2141223988 @default.
• W3200512237 cites W2142631525 @default.
• W3200512237 cites W2144205061 @default.
• W3200512237 cites W2150810615 @default.
• W3200512237 cites W2150956565 @default.
• W3200512237 cites W2162914074 @default.
• W3200512237 cites W2171768182 @default.
• W3200512237 cites W2180574028 @default.
• W3200512237 cites W2327256548 @default.
• W3200512237 cites W2409913424 @default.
• W3200512237 cites W2410857416 @default.
• W3200512237 cites W2479271599 @default.
• W3200512237 cites W2557533493 @default.
• W3200512237 cites W2580156077 @default.
• W3200512237 cites W2605878903 @default.
• W3200512237 cites W2607427115 @default.
• W3200512237 cites W2766272730 @default.
• W3200512237 cites W2766390497 @default.
• W3200512237 cites W2810735970 @default.
• W3200512237 cites W2893096669 @default.
• W3200512237 cites W2896350404 @default.
• W3200512237 cites W2986995731 @default.
• W3200512237 cites W2990199154 @default.
• W3200512237 cites W3034907970 @default.
• W3200512237 doi "https://doi.org/10.3390/biomedicines9091267" @default.
• W3200512237 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8468751" @default.
• W3200512237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34572453" @default.
• W3200512237 hasPublicationYear "2021" @default.
• W3200512237 type Work @default.
• W3200512237 sameAs 3200512237 @default.
• W3200512237 citedByCount "2" @default.
• W3200512237 countsByYear W32005122372022 @default.
• W3200512237 crossrefType "journal-article" @default.
• W3200512237 hasAuthorship W3200512237A5040342258 @default.
• W3200512237 hasBestOaLocation W32005122371 @default.
• W3200512237 hasConcept C10205521 @default.
• W3200512237 hasConcept C125473707 @default.
• W3200512237 hasConcept C126322002 @default.
• W3200512237 hasConcept C134018914 @default.
• W3200512237 hasConcept C142724271 @default.
• W3200512237 hasConcept C167734588 @default.
• W3200512237 hasConcept C169760540 @default.
• W3200512237 hasConcept C204232928 @default.
• W3200512237 hasConcept C2777025900 @default.
• W3200512237 hasConcept C2777348757 @default.
• W3200512237 hasConcept C2779652256 @default.
• W3200512237 hasConcept C2781294515 @default.
• W3200512237 hasConcept C28328180 @default.
• W3200512237 hasConcept C2992333117 @default.
• W3200512237 hasConcept C37753355 @default.
• W3200512237 hasConcept C54355233 @default.
• W3200512237 hasConcept C6061869 @default.
• W3200512237 hasConcept C71924100 @default.
• W3200512237 hasConcept C74864618 @default.

• next