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• W3200520705 abstract "Rationale: Reward-associated cues can acquire incentive motivational properties and invigorate reward-seeking actions via Pavlovian-to-instrumental transfer (PIT). Glutamatergic neurotrans-mission mediates the appetitive effects of reward-associated cues. We characterized the expres-sion of PIT and its mediation by metabotropic group II glutamate (mGlu2/3) receptor activity in female and male rats. Objectives: Across the sexes, we used PIT procedures to determine i) cue-triggered increases in incentive motivation for water reward (Experiment 1), ii) the respective influences of the mGlu2/3 receptor agonist LY379268 and reward devaluation by satiation on this effect (Experi-ment 2). Methods: Water-restricted male and female Sprague-Dawley rats learned to lever press for water. Separately, they learned that one of two auditory stimuli predicts free water (CS+ vs CS-). On PIT test days, the CS+ and CS- were presented non-contingently, and we measured effects on lever pressing under extinction (no water). In Experiment 1, we characterized PIT across the sex-es. In Experiment 2, we measured PIT after systemic LY379268 administration (0, 0.3 and 1 mg/kg), and water satiation, respectively. Results: Female and male rats showed similar PIT, with CS+ but not CS- presentations poten-tiating water-seeking behaviour. LY379268 (1 mg/kg) attenuated CS+ evoked increases in both water-associated lever pressing and conditioned approach to the water port. Reward devaluation attenuated both water-seeking and CS+ evoked conditioned approach behaviour. Conclusions: The sexes show similar cue-triggered increases in reward 'wanting', and water de-valuation suppresses both water seeking and cue-triggered anticipation of water reward. Finally, across the sexes, mGlu2/3 receptor activity mediates cue-triggered increases in reward 'wanting'. Keywords: Instrumental conditioning, Pavlovian conditioning, Pavlovian-to-instrumental trans-fer, glutamate, mGlu2/3 receptors, devaluation, sex differences" @default.
• W3200520705 created "2021-09-27" @default.
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• W3200520705 date "2021-09-17" @default.
• W3200520705 modified "2023-10-16" @default.
• W3200520705 title "Metabotropic group II glutamate receptors mediate cue-triggered increases in incentive motivation for reward" @default.
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• W3200520705 doi "https://doi.org/10.1101/2021.09.14.460377" @default.
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