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• W3200529034 abstract "The most common disabling symptom of osteoarthritis (OA) is pain. Clinical investigations using disease-specific animal models have increased our insights into the pathophysiology of osteoarthritic pain. As the prevalence of OA continues to rise and current available treatment options give less than optimal levels of pain relief, opportunities to develop treatments to address osteoarthritic pain are increasing. Targeted administration of local anesthetics along sensory/motor nerves can provide an alternative strategy for managing osteoarthritic pain. Moreover, the development of engineered therapeutic drug delivery systems may allow for sustained perineural delivery of local anesthetics as opposed to the traditional intraarticular joint injections. This review presents an overview of (1) the pathophysiology of persistent pain associated with OA of the hip, shoulder, and knee and (2) the emerging therapeutic role of local anesthetics in providing analgesia for joint-related pain symptoms. Osteoarthritic pain is one of the most common reasons patients seek medical attention. However, common oral analgesic treatments are fraught with several clinical challenges including off-target side-effects, addiction, and short duration of analgesic efficacy. Direct delivery of local anesthetics to the perineural space surrounding peripheral neurons is proving to be forthcoming clinical approach that may be superior to traditional analgesic approaches. This review describes current diagnostic and therapeutic approaches for osteoarthritis pain and the clinical data regarding local anesthetic injections for shoulder, hip, and knee joint pain. Furthermore, this review describes the future directions for clinical use of ultrasound-guidance for focal drug delivery and biomaterial drug delivery systems for sustained drug release which both may provide further advancements for analgesic treatments of osteoarthritis pain." @default.
• W3200529034 created "2021-09-27" @default.
• W3200529034 creator A5024744946 @default.
• W3200529034 creator A5054090020 @default.
• W3200529034 creator A5084630487 @default.
• W3200529034 date "2021-09-01" @default.
• W3200529034 modified "2023-10-18" @default.
• W3200529034 title "Perineural Local Anesthetic Treatments for Osteoarthritic Pain" @default.
• W3200529034 cites W124903722 @default.
• W3200529034 cites W1493918286 @default.
• W3200529034 cites W1503811432 @default.
• W3200529034 cites W1504831459 @default.
• W3200529034 cites W1514964607 @default.
• W3200529034 cites W1579204184 @default.
• W3200529034 cites W1588173730 @default.
• W3200529034 cites W1693493069 @default.
• W3200529034 cites W1816578835 @default.
• W3200529034 cites W1818993967 @default.
• W3200529034 cites W1925445634 @default.
• W3200529034 cites W1931104708 @default.
• W3200529034 cites W1932213429 @default.
• W3200529034 cites W1933270748 @default.
• W3200529034 cites W1963983800 @default.
• W3200529034 cites W1964517792 @default.
• W3200529034 cites W1966098353 @default.
• W3200529034 cites W1967057044 @default.
• W3200529034 cites W1967170359 @default.
• W3200529034 cites W1968460289 @default.
• W3200529034 cites W1969675091 @default.
• W3200529034 cites W1969929736 @default.
• W3200529034 cites W1971512621 @default.
• W3200529034 cites W1972861978 @default.
• W3200529034 cites W1975675610 @default.
• W3200529034 cites W1975849817 @default.
• W3200529034 cites W1980087436 @default.
• W3200529034 cites W1981607136 @default.
• W3200529034 cites W1982020985 @default.
• W3200529034 cites W1990076794 @default.
• W3200529034 cites W1995060296 @default.
• W3200529034 cites W1995663601 @default.
• W3200529034 cites W2009043578 @default.
• W3200529034 cites W2015463772 @default.
• W3200529034 cites W2017869529 @default.
• W3200529034 cites W2018117307 @default.
• W3200529034 cites W2023228758 @default.
• W3200529034 cites W2026774123 @default.
• W3200529034 cites W2027660675 @default.
• W3200529034 cites W2030033188 @default.
• W3200529034 cites W2030071902 @default.
• W3200529034 cites W2032927044 @default.
• W3200529034 cites W2034716696 @default.
• W3200529034 cites W2039748009 @default.
• W3200529034 cites W2047962160 @default.
• W3200529034 cites W2050708164 @default.
• W3200529034 cites W2054088330 @default.
• W3200529034 cites W2054379648 @default.
• W3200529034 cites W2055719889 @default.
• W3200529034 cites W2056599927 @default.
• W3200529034 cites W2058878920 @default.
• W3200529034 cites W2060263520 @default.
• W3200529034 cites W2060838250 @default.
• W3200529034 cites W2065209604 @default.
• W3200529034 cites W2071441738 @default.
• W3200529034 cites W2077242572 @default.
• W3200529034 cites W2077685376 @default.
• W3200529034 cites W2078942234 @default.
• W3200529034 cites W2080251825 @default.
• W3200529034 cites W2082500599 @default.
• W3200529034 cites W2083237289 @default.
• W3200529034 cites W2084568475 @default.
• W3200529034 cites W2089496280 @default.
• W3200529034 cites W2090486262 @default.
• W3200529034 cites W2098960917 @default.
• W3200529034 cites W2099657490 @default.
• W3200529034 cites W2099901505 @default.
• W3200529034 cites W2102308673 @default.
• W3200529034 cites W2102388585 @default.
• W3200529034 cites W2107653734 @default.
• W3200529034 cites W2108749700 @default.
• W3200529034 cites W2109443157 @default.
• W3200529034 cites W2110186288 @default.
• W3200529034 cites W2113661374 @default.
• W3200529034 cites W2116230226 @default.
• W3200529034 cites W2117794058 @default.
• W3200529034 cites W2120616812 @default.
• W3200529034 cites W2121270079 @default.
• W3200529034 cites W2127986829 @default.
• W3200529034 cites W2128882188 @default.
• W3200529034 cites W2129353150 @default.
• W3200529034 cites W2131895763 @default.
• W3200529034 cites W2132178051 @default.
• W3200529034 cites W2132491144 @default.
• W3200529034 cites W2139670497 @default.
• W3200529034 cites W2140115878 @default.
• W3200529034 cites W2140215285 @default.
• W3200529034 cites W2145197017 @default.
• W3200529034 cites W2146497898 @default.
• W3200529034 cites W2149303604 @default.

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