Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200530329> ?p ?o ?g. }
- W3200530329 abstract "Mitochondrial damage is a key feature of regulated cell death in neurons. In particular, mitochondrial outer membrane permeabilization (MOMP) has been proposed as a starting point for mitochondrial demise upon cellular stress. Potential mechanisms for MOMP presented in the literature include membrane pore formation by Bcl2-family proteins such as BID and BAX, oligomerization of voltage-dependent anion channels (VDACs) and hetero-oligomer formation of these proteins. In our study, we demonstrate a direct interaction between the voltage-dependent anion channel VDAC1 and the pro-apoptotic protein BID in dying neurons both in vitro and in vivo. Binding of BID to VDAC1 affects anion conductance through VDAC1 and is associated with glutamate-induced cell death in cultured neurons and ischemic brain injury. In cultured neurons, reducing VDAC1 expression significantly attenuates BID-induced hallmarks of mitochondrial damage such as mitochondrial fission, declined mitochondrial respiration, increased ROS production, and mitochondrial membrane potential breakdown. Our data highlight a critical role for VDAC1 as a mitochondrial receptor for activated BID, thereby serving as a key decision point between life and death in neurons." @default.
- W3200530329 created "2021-09-27" @default.
- W3200530329 creator A5005372827 @default.
- W3200530329 creator A5030534164 @default.
- W3200530329 creator A5031809822 @default.
- W3200530329 creator A5037316742 @default.
- W3200530329 creator A5040976043 @default.
- W3200530329 creator A5052528611 @default.
- W3200530329 creator A5053579288 @default.
- W3200530329 creator A5064422858 @default.
- W3200530329 creator A5066625527 @default.
- W3200530329 creator A5071925440 @default.
- W3200530329 creator A5080073536 @default.
- W3200530329 date "2021-09-14" @default.
- W3200530329 modified "2023-10-01" @default.
- W3200530329 title "Interaction between BID and VDAC1 is required for mitochondrial demise and cell death in neurons" @default.
- W3200530329 cites W1601030123 @default.
- W3200530329 cites W1644794975 @default.
- W3200530329 cites W1901072277 @default.
- W3200530329 cites W1964483580 @default.
- W3200530329 cites W1972195273 @default.
- W3200530329 cites W1973966118 @default.
- W3200530329 cites W1974575580 @default.
- W3200530329 cites W1974980101 @default.
- W3200530329 cites W1980262698 @default.
- W3200530329 cites W1980804643 @default.
- W3200530329 cites W1982998929 @default.
- W3200530329 cites W1986199954 @default.
- W3200530329 cites W1986568749 @default.
- W3200530329 cites W1989593508 @default.
- W3200530329 cites W1990891202 @default.
- W3200530329 cites W1991392283 @default.
- W3200530329 cites W1996789239 @default.
- W3200530329 cites W2009194850 @default.
- W3200530329 cites W2010399008 @default.
- W3200530329 cites W2013518954 @default.
- W3200530329 cites W2014999693 @default.
- W3200530329 cites W2023542615 @default.
- W3200530329 cites W2023983951 @default.
- W3200530329 cites W2025620957 @default.
- W3200530329 cites W2028134112 @default.
- W3200530329 cites W2030349442 @default.
- W3200530329 cites W2030864103 @default.
- W3200530329 cites W2031448195 @default.
- W3200530329 cites W2039892303 @default.
- W3200530329 cites W2049924143 @default.
- W3200530329 cites W2055448213 @default.
- W3200530329 cites W2057257618 @default.
- W3200530329 cites W2057384620 @default.
- W3200530329 cites W2068988368 @default.
- W3200530329 cites W2078301096 @default.
- W3200530329 cites W2078842089 @default.
- W3200530329 cites W2081690888 @default.
- W3200530329 cites W2087707919 @default.
- W3200530329 cites W2088337122 @default.
- W3200530329 cites W2097347505 @default.
- W3200530329 cites W2102034867 @default.
- W3200530329 cites W2103716630 @default.
- W3200530329 cites W2108775383 @default.
- W3200530329 cites W2129141040 @default.
- W3200530329 cites W2131987851 @default.
- W3200530329 cites W2162033191 @default.
- W3200530329 cites W2163630562 @default.
- W3200530329 cites W2321452523 @default.
- W3200530329 cites W2321530006 @default.
- W3200530329 cites W2321985754 @default.
- W3200530329 cites W2593342777 @default.
- W3200530329 cites W2792926837 @default.
- W3200530329 cites W2901167733 @default.
- W3200530329 cites W2940888331 @default.
- W3200530329 doi "https://doi.org/10.1101/2021.09.14.460262" @default.
- W3200530329 hasPublicationYear "2021" @default.
- W3200530329 type Work @default.
- W3200530329 sameAs 3200530329 @default.
- W3200530329 citedByCount "1" @default.
- W3200530329 countsByYear W32005303292023 @default.
- W3200530329 crossrefType "posted-content" @default.
- W3200530329 hasAuthorship W3200530329A5005372827 @default.
- W3200530329 hasAuthorship W3200530329A5030534164 @default.
- W3200530329 hasAuthorship W3200530329A5031809822 @default.
- W3200530329 hasAuthorship W3200530329A5037316742 @default.
- W3200530329 hasAuthorship W3200530329A5040976043 @default.
- W3200530329 hasAuthorship W3200530329A5052528611 @default.
- W3200530329 hasAuthorship W3200530329A5053579288 @default.
- W3200530329 hasAuthorship W3200530329A5064422858 @default.
- W3200530329 hasAuthorship W3200530329A5066625527 @default.
- W3200530329 hasAuthorship W3200530329A5071925440 @default.
- W3200530329 hasAuthorship W3200530329A5080073536 @default.
- W3200530329 hasBestOaLocation W32005303291 @default.
- W3200530329 hasConcept C104317684 @default.
- W3200530329 hasConcept C146587185 @default.
- W3200530329 hasConcept C173358068 @default.
- W3200530329 hasConcept C181911157 @default.
- W3200530329 hasConcept C185592680 @default.
- W3200530329 hasConcept C190283241 @default.
- W3200530329 hasConcept C200784783 @default.
- W3200530329 hasConcept C2779058106 @default.
- W3200530329 hasConcept C28859421 @default.
- W3200530329 hasConcept C31573885 @default.
- W3200530329 hasConcept C547475151 @default.