Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200536429> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W3200536429 endingPage "9962" @default.
- W3200536429 startingPage "9962" @default.
- W3200536429 abstract "Background: The phosphodiesterase type 5 inhibitor (PDE5I) tadalafil, in addition to its therapeutic role, has shown antioxidant effects in different in vivo models. Supplementation with antioxidants has received interest as a suitable tool for preventing or reducing exercise-related oxidative stress, possibly leading to the improvement of sport performance in athletes. However, the use/abuse of these substances must be evaluated not only within the context of amateur sport, but especially in competitions where elite athletes are more exposed to stressful physical practice. To date, very few human studies have addressed the influence of the administration of PDE5Is on redox balance in subjects with a fitness level comparable to elite athletes; therefore, the aim of this study was to investigate for the first time whether acute ingestion of tadalafil could affect plasma markers related to cellular damage, redox homeostasis, and blood polyamines levels in healthy subjects with an elevated cardiorespiratory fitness level. Methods: Healthy male volunteers (n = 12), with a VO2max range of 40.1–56.0 mL/(kg × min), were administered with a single dose of tadalafil (20 mg). Plasma molecules related to muscle damage and redox-homeostasis, such as creatine kinase (CK), lactate dehydrogenase (LDH), total antioxidant capacity (TAC), reduced/oxidized glutathione ratio (GSH/GSSG), free thiols (FTH), antioxidant enzyme activities (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)), as well as thiobarbituric acid reactive substances (TBARs), protein carbonyls (PrCAR), and polyamine levels (spermine (Spm) and spermidine (Spd)) were evaluated immediately before and 2, 6 and 24 hours after the acute tadalafil administration. Results: A single tadalafil administration induced an increase in CK and LDH plasma levels 24 after consumption. No effects were observed on redox homeostasis or antioxidant enzyme activities, and neither were they observed on the oxidation target molecules or polyamines levels. Conclusion: Our results show that in subjects with an elevated fitness level, a single administration of tadalafil induced a significant increase in muscle damage target without affecting plasma antioxidant status." @default.
- W3200536429 created "2021-09-27" @default.
- W3200536429 creator A5005882808 @default.
- W3200536429 creator A5033313702 @default.
- W3200536429 creator A5039910189 @default.
- W3200536429 creator A5040411208 @default.
- W3200536429 creator A5058936664 @default.
- W3200536429 creator A5062130972 @default.
- W3200536429 creator A5067276540 @default.
- W3200536429 creator A5073388562 @default.
- W3200536429 date "2021-09-22" @default.
- W3200536429 modified "2023-10-15" @default.
- W3200536429 title "Effect of Tadalafil Administration on Redox Homeostasis and Polyamine Levels in Healthy Men with High Level of Physical Activity" @default.
- W3200536429 doi "https://doi.org/10.3390/ijerph18199962" @default.
- W3200536429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8508218" @default.
- W3200536429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34639267" @default.
- W3200536429 hasPublicationYear "2021" @default.
- W3200536429 type Work @default.
- W3200536429 sameAs 3200536429 @default.
- W3200536429 citedByCount "3" @default.
- W3200536429 countsByYear W32005364292022 @default.
- W3200536429 crossrefType "journal-article" @default.
- W3200536429 hasAuthorship W3200536429A5005882808 @default.
- W3200536429 hasAuthorship W3200536429A5033313702 @default.
- W3200536429 hasAuthorship W3200536429A5039910189 @default.
- W3200536429 hasAuthorship W3200536429A5040411208 @default.
- W3200536429 hasAuthorship W3200536429A5058936664 @default.
- W3200536429 hasAuthorship W3200536429A5062130972 @default.
- W3200536429 hasAuthorship W3200536429A5067276540 @default.
- W3200536429 hasAuthorship W3200536429A5073388562 @default.
- W3200536429 hasBestOaLocation W32005364291 @default.
- W3200536429 hasConcept C126322002 @default.
- W3200536429 hasConcept C134018914 @default.
- W3200536429 hasConcept C151730666 @default.
- W3200536429 hasConcept C185592680 @default.
- W3200536429 hasConcept C2775838275 @default.
- W3200536429 hasConcept C2776151105 @default.
- W3200536429 hasConcept C2776768464 @default.
- W3200536429 hasConcept C2777352226 @default.
- W3200536429 hasConcept C2778004101 @default.
- W3200536429 hasConcept C2778760513 @default.
- W3200536429 hasConcept C2779343474 @default.
- W3200536429 hasConcept C2780816001 @default.
- W3200536429 hasConcept C2780829032 @default.
- W3200536429 hasConcept C2986274086 @default.
- W3200536429 hasConcept C31903555 @default.
- W3200536429 hasConcept C55493867 @default.
- W3200536429 hasConcept C71924100 @default.
- W3200536429 hasConcept C86803240 @default.
- W3200536429 hasConcept C98274493 @default.
- W3200536429 hasConceptScore W3200536429C126322002 @default.
- W3200536429 hasConceptScore W3200536429C134018914 @default.
- W3200536429 hasConceptScore W3200536429C151730666 @default.
- W3200536429 hasConceptScore W3200536429C185592680 @default.
- W3200536429 hasConceptScore W3200536429C2775838275 @default.
- W3200536429 hasConceptScore W3200536429C2776151105 @default.
- W3200536429 hasConceptScore W3200536429C2776768464 @default.
- W3200536429 hasConceptScore W3200536429C2777352226 @default.
- W3200536429 hasConceptScore W3200536429C2778004101 @default.
- W3200536429 hasConceptScore W3200536429C2778760513 @default.
- W3200536429 hasConceptScore W3200536429C2779343474 @default.
- W3200536429 hasConceptScore W3200536429C2780816001 @default.
- W3200536429 hasConceptScore W3200536429C2780829032 @default.
- W3200536429 hasConceptScore W3200536429C2986274086 @default.
- W3200536429 hasConceptScore W3200536429C31903555 @default.
- W3200536429 hasConceptScore W3200536429C55493867 @default.
- W3200536429 hasConceptScore W3200536429C71924100 @default.
- W3200536429 hasConceptScore W3200536429C86803240 @default.
- W3200536429 hasConceptScore W3200536429C98274493 @default.
- W3200536429 hasFunder F4320313983 @default.
- W3200536429 hasIssue "19" @default.
- W3200536429 hasLocation W32005364291 @default.
- W3200536429 hasLocation W32005364292 @default.
- W3200536429 hasLocation W32005364293 @default.
- W3200536429 hasLocation W32005364294 @default.
- W3200536429 hasOpenAccess W3200536429 @default.
- W3200536429 hasPrimaryLocation W32005364291 @default.
- W3200536429 hasRelatedWork W2003518555 @default.
- W3200536429 hasRelatedWork W2012945609 @default.
- W3200536429 hasRelatedWork W2056187023 @default.
- W3200536429 hasRelatedWork W2059407863 @default.
- W3200536429 hasRelatedWork W2186050858 @default.
- W3200536429 hasRelatedWork W2187603541 @default.
- W3200536429 hasRelatedWork W2213996271 @default.
- W3200536429 hasRelatedWork W2430757080 @default.
- W3200536429 hasRelatedWork W3214998341 @default.
- W3200536429 hasRelatedWork W4313039917 @default.
- W3200536429 hasVolume "18" @default.
- W3200536429 isParatext "false" @default.
- W3200536429 isRetracted "false" @default.
- W3200536429 magId "3200536429" @default.
- W3200536429 workType "article" @default.