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• W3200544324 endingPage "112180" @default.
• W3200544324 startingPage "112180" @default.
• W3200544324 abstract "The current work aims to study the nephroprotective potential of naringin (NG), a flavanone derived from citrus fruits, in methotrexate (MTX)-induced renal toxicity. Thirty male rats were divided into five groups; control group (IP saline), MTX group (IP single dose, 20 mg/kg), and three groups co-treated with MTX and naringin (IP daily dose; 20, 40, and 80 mg/kg, respectively). Kidney tissues were used to investigate renal function, oxidative stress, lipid peroxidation, and caspase-3 activity. Biochemical cytokine analysis was performed in addition to ultrastructural examinations of kidney tissue. When compared to the MTX-treated rats, MTX+NG significantly reduced the levels of urea, creatinine, MDA, NO, TNFα, IL-6, and caspase-3 activity. A significant increase in the levels of the antioxidant enzymes and GSH were also noted. Additionally, naringin ameliorated the apparent ultrastructural changes observed in the glomeruli and renal tubules of MTX-intoxicated rats. Noticeable structural improvements of glomerular lesions, proximal, and distal convoluted tubular epithelium were observed in MTX+NG treated animals, including podocytes with regular foot processes, perfectly organized filtration barrier, no signs of GBM thickening, organized brush border, and normal architecture of microvilli. Naringin (80 mg/kg) had the maximum amelioration effect. To the best of our knowledge, this is the first study to investigate the ultrastructural manifestations of naringin and/or MTX on the kidney of rats. Taken all, naringin has a potent therapeutic effect and can be used in adjuvant therapy to prevent MTX-induced nephrotoxicity. Nevertheless, the molecular mechanism underlying the nephroprotective capacity of naringin needs further investigation. • Naringin induced a marked decrease of renal injury markers in MTX-treated rats. • Naringin protected against redox imbalance of renal tissue in MTX-treated rats. • Naringin restored serum levels of TNF-α and IL-6 in a dose-dependent manner. • Naringin attenuated apoptotic changes and caspase-3 activity in MTX-treated rats. • Naringin preserved renal pathology alterations in the MTX-treated rats." @default.
• W3200544324 created "2021-09-27" @default.
• W3200544324 creator A5001759800 @default.
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• W3200544324 date "2021-11-01" @default.
• W3200544324 modified "2023-10-12" @default.
• W3200544324 title "Nephroprotective effect of naringin in methotrexate induced renal toxicity in male rats" @default.
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• W3200544324 doi "https://doi.org/10.1016/j.biopha.2021.112180" @default.
• W3200544324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34536756" @default.
• W3200544324 hasPublicationYear "2021" @default.
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