FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200545735> ?p ?o ?g. }

• W3200545735 abstract "Summary Circadian clocks increase fitness of organisms by adapting physiological and behavioral rhythms to the daily changes of light and temperature, caused by the Earth’ 24-hr rotation around its own axis. They consist of self-sustained molecular oscillators, maintained by negative feedback regulation of several clock genes, including period ( per ) and timeless ( tim ) in the fruit fly Drosophila melanogaster . This molecular clock is synchronized by light:dark and temperature cycles (Zeitgeber), and in turn drives rhythmic biological outputs, like the daily locomotor activity rhythms. While light generally is considered to be the more dominant, daily temperature cycles are sufficient for stable circadian clock synchronization. In Drosophila constant light leads to break down of the molecular clock and arrhythmic behavior, but clock function can be restored by simultaneously exposing the flies to temperature cycles, indicating their particular importance in regions experiencing long photoperiods or constant light. Here, we reveal that during temperature cycles, the deleterious effects of constant light on the clock are avoided by repressing the activity of the photoreceptor CRYPTOCHROME (CRY), which normally leads to light-dependent degradation of TIM. We show that CRY levels are repressed by Gq-PLC-ß signaling, operating within central clock neurons, thereby stabilizing TIM and promoting clock function during constant light and temperature cycles. Consistent with these findings, we reveal that a recently evolved and less light sensitive form of TIM, does not require Gq-PLC-ß signaling for maintaining clock function during constant light and temperature cycles. In summary, our results supply the molecular explanation for temperature synchronization in constant light, and how fruit flies can maintain clock function and rhythmic behavior in northern latitudes." @default.
• W3200545735 created "2021-09-27" @default.
• W3200545735 creator A5067637993 @default.
• W3200545735 creator A5073367842 @default.
• W3200545735 creator A5075054944 @default.
• W3200545735 creator A5077002391 @default.
• W3200545735 creator A5078675775 @default.
• W3200545735 creator A5087033216 @default.
• W3200545735 date "2020-03-27" @default.
• W3200545735 modified "2023-10-16" @default.
• W3200545735 title "A temperature-dependent molecular switch to adjust behavior to changing environmental conditions" @default.
• W3200545735 cites W1490293082 @default.
• W3200545735 cites W1605372070 @default.
• W3200545735 cites W1964204115 @default.
• W3200545735 cites W1964557069 @default.
• W3200545735 cites W1968548713 @default.
• W3200545735 cites W1979388618 @default.
• W3200545735 cites W1981265742 @default.
• W3200545735 cites W1984673374 @default.
• W3200545735 cites W1985309857 @default.
• W3200545735 cites W1987956257 @default.
• W3200545735 cites W1989868645 @default.
• W3200545735 cites W1993592229 @default.
• W3200545735 cites W1998371106 @default.
• W3200545735 cites W2000183670 @default.
• W3200545735 cites W2001140892 @default.
• W3200545735 cites W2012321776 @default.
• W3200545735 cites W2016730858 @default.
• W3200545735 cites W2020146248 @default.
• W3200545735 cites W2021573697 @default.
• W3200545735 cites W2028563901 @default.
• W3200545735 cites W2031483444 @default.
• W3200545735 cites W2044222466 @default.
• W3200545735 cites W2052267173 @default.
• W3200545735 cites W2071052296 @default.
• W3200545735 cites W2076696166 @default.
• W3200545735 cites W2086967162 @default.
• W3200545735 cites W2095299680 @default.
• W3200545735 cites W2112143419 @default.
• W3200545735 cites W2121321456 @default.
• W3200545735 cites W2124923401 @default.
• W3200545735 cites W2137798105 @default.
• W3200545735 cites W2142166311 @default.
• W3200545735 cites W2146575770 @default.
• W3200545735 cites W2161168395 @default.
• W3200545735 cites W2171909239 @default.
• W3200545735 cites W2177863086 @default.
• W3200545735 cites W2296711894 @default.
• W3200545735 cites W2511548209 @default.
• W3200545735 cites W2529131874 @default.
• W3200545735 cites W2768954983 @default.
• W3200545735 cites W2788464253 @default.
• W3200545735 cites W2801508417 @default.
• W3200545735 cites W2803491895 @default.
• W3200545735 cites W2807884764 @default.
• W3200545735 cites W4236619403 @default.
• W3200545735 hasPublicationYear "2020" @default.
• W3200545735 type Work @default.
• W3200545735 sameAs 3200545735 @default.
• W3200545735 citedByCount "0" @default.
• W3200545735 crossrefType "posted-content" @default.
• W3200545735 hasAuthorship W3200545735A5067637993 @default.
• W3200545735 hasAuthorship W3200545735A5073367842 @default.
• W3200545735 hasAuthorship W3200545735A5075054944 @default.
• W3200545735 hasAuthorship W3200545735A5077002391 @default.
• W3200545735 hasAuthorship W3200545735A5078675775 @default.
• W3200545735 hasAuthorship W3200545735A5087033216 @default.
• W3200545735 hasBestOaLocation W32005457351 @default.
• W3200545735 hasConcept C104317684 @default.
• W3200545735 hasConcept C114614502 @default.
• W3200545735 hasConcept C121332964 @default.
• W3200545735 hasConcept C121446783 @default.
• W3200545735 hasConcept C125168821 @default.
• W3200545735 hasConcept C12554922 @default.
• W3200545735 hasConcept C135343436 @default.
• W3200545735 hasConcept C144543706 @default.
• W3200545735 hasConcept C169760540 @default.
• W3200545735 hasConcept C184720557 @default.
• W3200545735 hasConcept C184738001 @default.
• W3200545735 hasConcept C21786239 @default.
• W3200545735 hasConcept C24890656 @default.
• W3200545735 hasConcept C2778562939 @default.
• W3200545735 hasConcept C2778880379 @default.
• W3200545735 hasConcept C2780104201 @default.
• W3200545735 hasConcept C2781291010 @default.
• W3200545735 hasConcept C33923547 @default.
• W3200545735 hasConcept C38606739 @default.
• W3200545735 hasConcept C54355233 @default.
• W3200545735 hasConcept C86803240 @default.
• W3200545735 hasConcept C95444343 @default.
• W3200545735 hasConceptScore W3200545735C104317684 @default.
• W3200545735 hasConceptScore W3200545735C114614502 @default.
• W3200545735 hasConceptScore W3200545735C121332964 @default.
• W3200545735 hasConceptScore W3200545735C121446783 @default.
• W3200545735 hasConceptScore W3200545735C125168821 @default.
• W3200545735 hasConceptScore W3200545735C12554922 @default.
• W3200545735 hasConceptScore W3200545735C135343436 @default.
• W3200545735 hasConceptScore W3200545735C144543706 @default.
• W3200545735 hasConceptScore W3200545735C169760540 @default.
• W3200545735 hasConceptScore W3200545735C184720557 @default.

• next