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- W3200548788 abstract "Ex vivo lung perfusion (EVLP) is an excellent platform to apply novel therapeutics, such as gene and cell therapies, before lung transplantation. We investigated the concept of human donor lung engineering during EVLP by combining gene and cell therapies. Premodified cryopreserved mesenchymal stromal cells with augmented anti-inflammatory interleukin-10 production (MSCIL-10) were administered during EVLP to human lungs that had various degrees of underlying lung injury. Cryopreserved MSCIL-10 had excellent viability, and they immediately and efficiently elevated perfusate and lung tissue IL-10 levels during EVLP. However, MSCIL-10 function was compromised by the poor metabolic conditions present in the most damaged lungs. Similarly, exposing cultured MSCIL-10 to poor metabolic, and especially acidic, conditions decreased their IL-10 production. In conclusion, we found that off-the-shelf MSCIL-10 therapy of human lungs during EVLP is safe and feasible, and results in rapid IL-10 elevation, and that the acidic target-tissue microenvironment may compromise the efficacy of cell-based therapies." @default.
- W3200548788 created "2021-09-27" @default.
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- W3200548788 date "2021-12-01" @default.
- W3200548788 modified "2023-10-13" @default.
- W3200548788 title "Engineered mesenchymal stromal cell therapy during human lung ex vivo lung perfusion is compromised by acidic lung microenvironment" @default.
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- W3200548788 doi "https://doi.org/10.1016/j.omtm.2021.05.018" @default.
- W3200548788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8516994" @default.
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- W3200548788 hasPublicationYear "2021" @default.
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