FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200560872> ?p ?o ?g. }

• W3200560872 abstract "Nanotoxicology is an emerging field employed in the assessment of unintentional hazardous effects produced by nanoparticles (NPs) impacting human health and the environment. The nanotoxicity affects the range between induction of cellular stress and cytotoxicity. The reasons so far reported for these toxicological effects are due to their variable sizes with high surface areas, shape, charge, and physicochemical properties, which upon interaction with the biological components may influence their functioning and result in adverse outcomes (AO). Thus, understanding the risk produced by these materials now is an important safety concern for the development of nanotechnology and nanomedicine. Since the time nanotoxicology has evolved, the methods employed have been majorly relied on in vitro cell-based evaluations, while these simple methods may not predict the complexity involved in preclinical and clinical conditions concerning pharmacokinetics, organ toxicity, and toxicities evidenced through multiple cellular levels. The safety profiles of nanoscale nanomaterials and nanoformulations in the delivery of drugs and therapeutic applications are of considerable concern. In addition, the safety assessment for new nanomedicine formulas lacks regulatory standards. Though the in vivo studies are greatly needed, the end parameters used for risk assessment are not predicting the possible toxic effects produced by various nanoformulations. On the other side, due to increased restrictions on animal usage and demand for the need for high-throughput assays, there is a need for developing and exploring novel methods to evaluate NPs safety concerns. The progress made in molecular biology and the availability of several modern techniques may offer novel and innovative methods to evaluate the toxicological behavior of different NPs by using single cells, cell population, and whole organisms. This review highlights the recent novel methods developed for the evaluation of the safety impacts of NPs and attempts to solve the problems that come with risk assessment. The relevance of investigating adverse outcome pathways (AOPs) in nanotoxicology has been stressed in particular." @default.
• W3200560872 created "2021-09-27" @default.
• W3200560872 creator A5001222816 @default.
• W3200560872 creator A5018148019 @default.
• W3200560872 creator A5065347953 @default.
• W3200560872 creator A5078478201 @default.
• W3200560872 creator A5080225933 @default.
• W3200560872 date "2021-09-09" @default.
• W3200560872 modified "2023-09-25" @default.
• W3200560872 title "Novel Methods and Approaches for Safety Evaluation of Nanoparticle Formulations: A Focus Towards In Vitro Models and Adverse Outcome Pathways" @default.
• W3200560872 cites W1222186586 @default.
• W3200560872 cites W1418478703 @default.
• W3200560872 cites W1509898865 @default.
• W3200560872 cites W1543814382 @default.
• W3200560872 cites W1552431667 @default.
• W3200560872 cites W1561086229 @default.
• W3200560872 cites W1567847444 @default.
• W3200560872 cites W1579782115 @default.
• W3200560872 cites W1605460006 @default.
• W3200560872 cites W1616274371 @default.
• W3200560872 cites W1622934337 @default.
• W3200560872 cites W1706562550 @default.
• W3200560872 cites W1737029134 @default.
• W3200560872 cites W1793124009 @default.
• W3200560872 cites W1829229940 @default.
• W3200560872 cites W1848527143 @default.
• W3200560872 cites W1966199977 @default.
• W3200560872 cites W1966318343 @default.
• W3200560872 cites W1968691118 @default.
• W3200560872 cites W1971649391 @default.
• W3200560872 cites W1972264015 @default.
• W3200560872 cites W1973829219 @default.
• W3200560872 cites W1981873046 @default.
• W3200560872 cites W1982012132 @default.
• W3200560872 cites W1982387635 @default.
• W3200560872 cites W1983187325 @default.
• W3200560872 cites W1984266984 @default.
• W3200560872 cites W1985191334 @default.
• W3200560872 cites W1985724323 @default.
• W3200560872 cites W1986334126 @default.
• W3200560872 cites W1987932141 @default.
• W3200560872 cites W1992350696 @default.
• W3200560872 cites W1993198696 @default.
• W3200560872 cites W1996189501 @default.
• W3200560872 cites W1997027608 @default.
• W3200560872 cites W1998464888 @default.
• W3200560872 cites W1999186969 @default.
• W3200560872 cites W2000257056 @default.
• W3200560872 cites W2001731312 @default.
• W3200560872 cites W2004376131 @default.
• W3200560872 cites W2006791781 @default.
• W3200560872 cites W2008939735 @default.
• W3200560872 cites W2009309580 @default.
• W3200560872 cites W2013520568 @default.
• W3200560872 cites W2015680598 @default.
• W3200560872 cites W2018062088 @default.
• W3200560872 cites W2020448183 @default.
• W3200560872 cites W2022212810 @default.
• W3200560872 cites W2025531336 @default.
• W3200560872 cites W2026618442 @default.
• W3200560872 cites W2029701310 @default.
• W3200560872 cites W2031472251 @default.
• W3200560872 cites W2031785809 @default.
• W3200560872 cites W2033443844 @default.
• W3200560872 cites W2034343019 @default.
• W3200560872 cites W2035320088 @default.
• W3200560872 cites W2037124284 @default.
• W3200560872 cites W2038320761 @default.
• W3200560872 cites W2038684735 @default.
• W3200560872 cites W2045899482 @default.
• W3200560872 cites W2048644480 @default.
• W3200560872 cites W2049519332 @default.
• W3200560872 cites W2049957604 @default.
• W3200560872 cites W2050698056 @default.
• W3200560872 cites W2054068435 @default.
• W3200560872 cites W2056565632 @default.
• W3200560872 cites W2057166532 @default.
• W3200560872 cites W2057341990 @default.
• W3200560872 cites W2058936522 @default.
• W3200560872 cites W2062866488 @default.
• W3200560872 cites W2063060349 @default.
• W3200560872 cites W2063138798 @default.
• W3200560872 cites W2063304359 @default.
• W3200560872 cites W2064176735 @default.
• W3200560872 cites W2065007266 @default.
• W3200560872 cites W2065342600 @default.
• W3200560872 cites W2069234607 @default.
• W3200560872 cites W2070407470 @default.
• W3200560872 cites W2070445316 @default.
• W3200560872 cites W2075275335 @default.
• W3200560872 cites W2079954478 @default.
• W3200560872 cites W2081826664 @default.
• W3200560872 cites W2082493189 @default.
• W3200560872 cites W2084387129 @default.
• W3200560872 cites W2085043731 @default.
• W3200560872 cites W2085420920 @default.
• W3200560872 cites W2086943348 @default.
• W3200560872 cites W2089228375 @default.
• W3200560872 cites W2089452715 @default.
• W3200560872 cites W2090507586 @default.

• next