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- W3200566738 abstract "Early after radiation exposure, depletion ofcritical immune cell populations in irradiated individuals canresult in ineffective immune responses, putting them at increasedrisk of secondary infections. Data from Chernobyl, as well as fromthe bone marrow transplant literature, suggest that the irradiatedlung is at particular risk for developing pulmonary complicationslate after exposure. Previous work has demonstrated that there arealtered and persistent inflammatory and immune changes followingradiation injury in the lung, and it is hypothesized that thechronicity of these changes may affect the ability of the lung tomount a functional response to a pulmonary challenge occurring inthe weeks to months after exposure. We demonstrate that irradiatedC57Bl/6J mice infected with influenza A virus (HKx31) at 10 weekspost irradiation have increased mortality following infection andfail to regain the body weight lost during infection; effects thatwere dependent on the radiation dose. This exacerbated responseoccurred despite these animals’ ability to mount an effectivevirus-specific response, including viral clearance. Interestingly,irradiated animals displayed a prolonged increase in protein leakinto the lung post infection, suggesting this altered response maybe due to an effect on epithelial repair rather than on the immuneresponse. In fact, when irradiated animals were allowed more timeto recover, they developed exacerbated lung pathology, includingpersistent edema, inflammation and fibrosis. This pathology wasassociated with an accelerated decline in pulmonary function, andsuggests a secondary infection may also potentiateradiation-induced injury to the lung. Using Clara cell secretoryprotein (CCSP) as a marker for bronchiolar epithelial Clara cells, we identified a radiation-induced reduction in CCSP mRNA andan associated reduction in CCSP-expressing Clara cells in thelung. Following infection, recovery of CCSP was significantlydelayed with radiation. Collectively, this thesis demonstratesthat persistent sub-clinical injury in the lung post irradiationcan exacerbate responses to a subsequent pulmonary challengeoccurring later after exposure, and indicates a possible radiationeffect on the epithelial repair process. Importantly, this workidentifies a longterm risk of pulmonary complications resultingfrom respiratory infections in individuals whose lungs have beenirradiated." @default.
- W3200566738 created "2021-09-27" @default.
- W3200566738 creator A5011243725 @default.
- W3200566738 date "2013-01-01" @default.
- W3200566738 modified "2023-09-24" @default.
- W3200566738 title "Influenza A Virus Infection Reveals Sub-clinicalRadiation Injury in the Lung" @default.
- W3200566738 hasPublicationYear "2013" @default.
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