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• W3200573459 abstract "Interleukin-1β is a key pro-inflammatory cytokine functioning in initiation of inflammatory responses against bacterial- and viral-infections. In the present study, a putative IL-1β counterpart was identified from Siberian sturgeon (Acipenser baeri) and designated as AbIL-1β. The Abil-1β cDNA sequence consists of 1130 bp with an open reading frame (ORF) of 585 bp, which encodes a 194 amino acid (aa) protein. Multiple amino acid sequence alignment revealed that a possible mature peptide could start at Leu18, although no cut site for ICE (IL-1β converting enzyme) enzyme was present in Siberian sturgeon IL-1β. Even if AbIL-1β shares a relative low identity (33.6%) with another sturgeon type II IL-1β gene from Acipenser dabryanus, they still clustered together in phylogenetic tree. Endogenous Abil-1β was highly expressed in brain, blood, head kidney and spleen of healthy Siberian sturgeon, and remarkably up regulated in head kidney, spleen, and liver upon Aeromonas hydrophila (A.h) challenge. Consistently, in vitro stimulation test using heat-killed A.h and LPS significantly increased Abil-1β transcripts of primary spleen cells. To investigate the bactericidal capability of AbIL-1β, recombinant AbIL-1β (rAbIL-1β) was generated by prokaryotes. Pre-injection of rAbIL-1β reduced the bacterial load in sturgeon spleen after A.h infection. Further, rAbIL-1β was served as feed additive and demonstrated to enhance hybrid sturgeon's defense against A.h infection by increased expressional levels of immune-related genes (IL-1β, IL-6, IL-8, IgM and MHCIIβ), elevated activities of serum lysosome, ACH50, and MPO, as well as higher percent survival. In summary, the current results suggested that AbIL-1β functions in immune regulation and could improve sturgeon's resistance to bacterial infection." @default.
• W3200573459 created "2021-09-27" @default.
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• W3200573459 date "2021-11-01" @default.
• W3200573459 modified "2023-10-01" @default.
• W3200573459 title "An IL-1β homologue induced inflammation and antibacterial immune defense in Siberian sturgeon (Acipenser baeri)" @default.
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• W3200573459 doi "https://doi.org/10.1016/j.fsi.2021.08.030" @default.
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