FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200577958> ?p ?o ?g. }

• W3200577958 endingPage "648" @default.
• W3200577958 startingPage "636" @default.
• W3200577958 abstract "<b><i>Introduction:</i></b> Neurons expressing estrogen receptor (ER) ɑ in the arcuate (ARC) and ventromedial (VMH) nuclei of the hypothalamus sex-specifically control energy homeostasis, sexual behavior, and bone density. Females have more ERɑ neurons in the VMH and ARC than males, and the sex difference in the VMH is eliminated by neonatal treatment with testosterone or a DNA methylation inhibitor. <b><i>Objective:</i></b> Here, we tested the roles of testosterone and DNA methylation/demethylation in development of ERɑ in the ARC. <b><i>Methods:</i></b> ERɑ was examined at birth and weaning in mice that received vehicle or testosterone subcutaneously, and vehicle or DNA methyltransferase inhibitor intracerebroventricularly, as neonates. To examine effects of DNA demethylation on the ERɑ cell number in the ARC, mice were treated neonatally with small interfering RNAs against ten-eleven translocase enzymes. The methylation status of the ERɑ gene (<i>Esr1</i>) was determined in the ARC and VMH using pyrosequencing of bisulfite-converted DNA. <b><i>Results:</i></b> A sex difference in ERɑ in the ARC, favoring females, developed between birth and weaning and was due to programming effects of testosterone. Neonatal inhibition of DNA methylation decreased ERɑ in the ARC of females, and an inhibition of <underline>de</underline>methylation increased ERɑ in the ARC of males. The promoter region of <i>Esr1</i> exhibited a small sex difference in percent of total methylation in the ARC (females &#x3e; males) that was opposite to that in the VMH (males &#x3e; females). <b><i>Conclusion:</i></b> DNA methylation and demethylation regulate ERɑ cell number in the ARC, and methylation correlates with activation of <i>Esr1</i> in this region." @default.
• W3200577958 created "2021-09-27" @default.
• W3200577958 creator A5001574508 @default.
• W3200577958 creator A5002618250 @default.
• W3200577958 creator A5021106334 @default.
• W3200577958 creator A5023870943 @default.
• W3200577958 creator A5050620760 @default.
• W3200577958 creator A5088504894 @default.
• W3200577958 creator A5090688289 @default.
• W3200577958 date "2021-09-21" @default.
• W3200577958 modified "2023-10-06" @default.
• W3200577958 title "DNA Methylation and Demethylation Underlie the Sex Difference in Estrogen Receptor Alpha in the Arcuate Nucleus" @default.
• W3200577958 cites W1494091679 @default.
• W3200577958 cites W1499793237 @default.
• W3200577958 cites W1589868346 @default.
• W3200577958 cites W1678472442 @default.
• W3200577958 cites W1749054014 @default.
• W3200577958 cites W1945092611 @default.
• W3200577958 cites W1967340797 @default.
• W3200577958 cites W1968179768 @default.
• W3200577958 cites W1976626368 @default.
• W3200577958 cites W1978897662 @default.
• W3200577958 cites W1984325684 @default.
• W3200577958 cites W1987321973 @default.
• W3200577958 cites W1990004044 @default.
• W3200577958 cites W1990689143 @default.
• W3200577958 cites W2000877244 @default.
• W3200577958 cites W2005515453 @default.
• W3200577958 cites W2011951374 @default.
• W3200577958 cites W2013865699 @default.
• W3200577958 cites W2014166259 @default.
• W3200577958 cites W2014852291 @default.
• W3200577958 cites W2015793781 @default.
• W3200577958 cites W2017502764 @default.
• W3200577958 cites W2026463002 @default.
• W3200577958 cites W2027488186 @default.
• W3200577958 cites W2028240961 @default.
• W3200577958 cites W2029742174 @default.
• W3200577958 cites W2030896169 @default.
• W3200577958 cites W2035435760 @default.
• W3200577958 cites W2048117553 @default.
• W3200577958 cites W2052227813 @default.
• W3200577958 cites W2052593207 @default.
• W3200577958 cites W2054523001 @default.
• W3200577958 cites W2055986128 @default.
• W3200577958 cites W2056607606 @default.
• W3200577958 cites W2056741515 @default.
• W3200577958 cites W2059099579 @default.
• W3200577958 cites W2060309994 @default.
• W3200577958 cites W2061578142 @default.
• W3200577958 cites W2066166801 @default.
• W3200577958 cites W2068243846 @default.
• W3200577958 cites W2069122492 @default.
• W3200577958 cites W2073358648 @default.
• W3200577958 cites W2081161251 @default.
• W3200577958 cites W2081602009 @default.
• W3200577958 cites W2083535257 @default.
• W3200577958 cites W2085414352 @default.
• W3200577958 cites W2091601353 @default.
• W3200577958 cites W2092293354 @default.
• W3200577958 cites W2097483311 @default.
• W3200577958 cites W2100232545 @default.
• W3200577958 cites W2105116198 @default.
• W3200577958 cites W2121417064 @default.
• W3200577958 cites W2127192982 @default.
• W3200577958 cites W2133265697 @default.
• W3200577958 cites W2133925293 @default.
• W3200577958 cites W2142047617 @default.
• W3200577958 cites W2143858605 @default.
• W3200577958 cites W2148521032 @default.
• W3200577958 cites W2152451432 @default.
• W3200577958 cites W2152642144 @default.
• W3200577958 cites W2158060077 @default.
• W3200577958 cites W2170036922 @default.
• W3200577958 cites W2465026363 @default.
• W3200577958 cites W2508067163 @default.
• W3200577958 cites W2521981506 @default.
• W3200577958 cites W2606674058 @default.
• W3200577958 cites W2609789137 @default.
• W3200577958 cites W2624072506 @default.
• W3200577958 cites W2688822502 @default.
• W3200577958 cites W2746853305 @default.
• W3200577958 cites W2785429866 @default.
• W3200577958 cites W2899748807 @default.
• W3200577958 cites W2910496583 @default.
• W3200577958 cites W2964983449 @default.
• W3200577958 cites W2990751675 @default.
• W3200577958 cites W3027569065 @default.
• W3200577958 cites W3130668029 @default.
• W3200577958 doi "https://doi.org/10.1159/000519671" @default.
• W3200577958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34547753" @default.
• W3200577958 hasPublicationYear "2021" @default.
• W3200577958 type Work @default.
• W3200577958 sameAs 3200577958 @default.
• W3200577958 citedByCount "6" @default.
• W3200577958 countsByYear W32005779582023 @default.
• W3200577958 crossrefType "journal-article" @default.
• W3200577958 hasAuthorship W3200577958A5001574508 @default.

• next