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- W3200609871 endingPage "6000" @default.
- W3200609871 startingPage "5993" @default.
- W3200609871 abstract "Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent single-gene disorder leading to renal failure. Current therapies are aimed to treat renal and extrarenal complications of ADPKD, but improved knowledge of the pathophysiological mechanisms leading to the generation and growth of cysts has permitted the identification of new drug candidates for clinical trials. Among these, in this review, we will examine above all the role of metformin, hypothesized to be able to activate the AMP-activated protein kinase (AMPK) pathway and potentially modulate some mechanisms implicated in the onset and the growth of the cysts." @default.
- W3200609871 created "2021-09-27" @default.
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- W3200609871 date "2021-09-01" @default.
- W3200609871 modified "2023-10-02" @default.
- W3200609871 title "Retarding Progression of Chronic Kidney Disease in Autosomal Dominant Polycystic Kidney Disease with Metformin and Other Therapies: An Update of New Insights" @default.
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- W3200609871 doi "https://doi.org/10.2147/ijgm.s305491" @default.
- W3200609871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8473846" @default.