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• W3200647865 abstract "Mechanisms underlying anxiety disorders remain elusive despite the discovery of several associated genes. We constructed the protein-protein interaction networks (interactomes) of six anxiety disorders and noted enrichment for striatal expression among common genes in the interactomes. Five of these interactomes shared distinctive overlaps with the interactomes of genes that were differentially expressed in two striatal compartments (striosomes and matrix). Generalized anxiety disorder and social anxiety disorder interactomes showed exclusive and statistically significant overlaps with the striosome and matrix interactomes, respectively. Systematic gene expression analysis with the anxiety disorder interactomes constrained to contain only those genes that were shared with striatal compartment interactomes revealed a bifurcation among the disorders, which was influenced by the anterior cingulate cortex, nucleus accumbens, amygdala and hippocampus, and the dopaminergic signaling pathway. Our results indicate that the functionally distinct striatal pathways constituted by the striosome and the matrix may influence the etiological differentiation of various anxiety disorders." @default.
• W3200647865 created "2021-09-27" @default.
• W3200647865 creator A5000049528 @default.
• W3200647865 creator A5039956503 @default.
• W3200647865 creator A5066367676 @default.
• W3200647865 creator A5077505492 @default.
• W3200647865 creator A5077671596 @default.
• W3200647865 date "2021-09-15" @default.
• W3200647865 modified "2023-09-27" @default.
• W3200647865 title "Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes" @default.
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