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- W3200653922 abstract "The molecular mechanisms by which dietary fruits and vegetables confer cardiometabolic benefits remain poorly understood. Historically, these beneficial properties have been attributed to the antioxidant activity of flavonoids. Here, we reveal that the host metabolic benefits associated with flavonoid consumption actually hinge on gut microbial metabolism. We show that a single gut microbial flavonoid catabolite is sufficient to reduce diet-induced cardiometabolic disease burden in mice. Dietary supplementation with elderberry extract attenuated obesity and continuous delivery of the catabolite 4-hydroxphenylacetic acid was sufficient to reverse hepatic steatosis. Analysis of human gut metagenomes revealed that under one percent contains a flavonol catabolic pathway, underscoring the rarity of this process. Our study will impact the design of dietary and probiotic interventions to complement traditional cardiometabolic treatment strategies." @default.
- W3200653922 created "2021-09-27" @default.
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- W3200653922 date "2021-09-16" @default.
- W3200653922 modified "2023-10-18" @default.
- W3200653922 title "A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis" @default.
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- W3200653922 doi "https://doi.org/10.1101/2021.09.16.460661" @default.
- W3200653922 hasPublicationYear "2021" @default.
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