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- W3200655967 abstract "Background: Indomenthyl is an innovative anti-inflammatory drug with a high analgesic activity. Indomenthyl releases indomethacin under the influence of neutrophil esterases in the inflammation focus. Methodology/results: This research is aimed at developing a highly sensitive method for the quantitative determination of indomenthyl and its active metabolite indomethacin in rabbit plasma by HPLC-MS/MS. Protein precipitation and extraction with acetonitrile were used for analyte isolation from plasma according to the QuEChERS principle. The target quantitative ion pairs m/z were respectively 496.4 → 358.0 for indomenthyl, 358.0 → 139.5 for indomethacin, and 340.1 → 202.1 for the IS. Conclusion: The calibration curve was linear over the range 0.1-1000 ng mL-1. The technique was applied to the pharmacokinetic study at a dose of 25 mg kg-1 to rabbits." @default.
- W3200655967 created "2021-09-27" @default.
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- W3200655967 date "2021-01-01" @default.
- W3200655967 modified "2023-09-24" @default.
- W3200655967 title "Quantitative determination of new anti-inflammatory drug indomenthyl and its metabolite in rabbit plasma by HPLC-MS/MS" @default.
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- W3200655967 doi "https://doi.org/10.1039/d1ay01220g" @default.
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