Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200667677> ?p ?o ?g. }
- W3200667677 endingPage "111567" @default.
- W3200667677 startingPage "111567" @default.
- W3200667677 abstract "NAD+ is a fundamental molecule in human life and health as it participates in energy metabolism, cell signalling, mitochondrial homeostasis, and in dictating cell survival or death. Emerging evidence from preclinical and human studies indicates an age-dependent reduction of cellular NAD+, possibly due to reduced synthesis and increased consumption. In preclinical models, NAD+ repletion extends healthspan and / or lifespan and mitigates several conditions, such as premature ageing diseases and neurodegenerative diseases. These findings suggest that NAD+ replenishment through NAD+ precursors has great potential as a therapeutic target for ageing and age-predisposed diseases, such as Alzheimer's disease. Here, we provide an updated review on the biological activity, safety, and possible side effects of NAD+ precursors in preclinical and clinical studies. Major NAD+ precursors focused on by this review are nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), and the new discovered dihydronicotinamide riboside (NRH). In summary, NAD+ precursors have an exciting therapeutic potential for ageing, metabolic and neurodegenerative diseases." @default.
- W3200667677 created "2021-09-27" @default.
- W3200667677 creator A5016091825 @default.
- W3200667677 creator A5021486533 @default.
- W3200667677 creator A5048788845 @default.
- W3200667677 creator A5076675975 @default.
- W3200667677 creator A5081264656 @default.
- W3200667677 date "2021-10-01" @default.
- W3200667677 modified "2023-10-16" @default.
- W3200667677 title "Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing" @default.
- W3200667677 cites W1483624903 @default.
- W3200667677 cites W1528599353 @default.
- W3200667677 cites W1850059402 @default.
- W3200667677 cites W1852538637 @default.
- W3200667677 cites W1920018418 @default.
- W3200667677 cites W1959721425 @default.
- W3200667677 cites W1970554352 @default.
- W3200667677 cites W1973901371 @default.
- W3200667677 cites W1978814196 @default.
- W3200667677 cites W1989674299 @default.
- W3200667677 cites W1990201789 @default.
- W3200667677 cites W1991238493 @default.
- W3200667677 cites W1996177596 @default.
- W3200667677 cites W2012043504 @default.
- W3200667677 cites W2031050244 @default.
- W3200667677 cites W2038011036 @default.
- W3200667677 cites W2040414192 @default.
- W3200667677 cites W2041552603 @default.
- W3200667677 cites W2045266309 @default.
- W3200667677 cites W2046299720 @default.
- W3200667677 cites W2047898810 @default.
- W3200667677 cites W2048596172 @default.
- W3200667677 cites W2048878532 @default.
- W3200667677 cites W2053124968 @default.
- W3200667677 cites W2053806684 @default.
- W3200667677 cites W2054866841 @default.
- W3200667677 cites W2068128334 @default.
- W3200667677 cites W2068734116 @default.
- W3200667677 cites W2074369180 @default.
- W3200667677 cites W2082393205 @default.
- W3200667677 cites W2086038769 @default.
- W3200667677 cites W2087344458 @default.
- W3200667677 cites W2089838011 @default.
- W3200667677 cites W2092544807 @default.
- W3200667677 cites W2095061901 @default.
- W3200667677 cites W2097948853 @default.
- W3200667677 cites W2098215193 @default.
- W3200667677 cites W2103493042 @default.
- W3200667677 cites W2114382609 @default.
- W3200667677 cites W2118647245 @default.
- W3200667677 cites W2120276500 @default.
- W3200667677 cites W2124276356 @default.
- W3200667677 cites W2152101492 @default.
- W3200667677 cites W2157296254 @default.
- W3200667677 cites W2163921018 @default.
- W3200667677 cites W2164897814 @default.
- W3200667677 cites W2168443670 @default.
- W3200667677 cites W2171391341 @default.
- W3200667677 cites W2171748049 @default.
- W3200667677 cites W2191745121 @default.
- W3200667677 cites W2197446758 @default.
- W3200667677 cites W2221731984 @default.
- W3200667677 cites W2284984697 @default.
- W3200667677 cites W2296494566 @default.
- W3200667677 cites W2296761075 @default.
- W3200667677 cites W2343193821 @default.
- W3200667677 cites W2427895239 @default.
- W3200667677 cites W2530388030 @default.
- W3200667677 cites W2530753724 @default.
- W3200667677 cites W2531686927 @default.
- W3200667677 cites W2546015443 @default.
- W3200667677 cites W2614937654 @default.
- W3200667677 cites W2722324655 @default.
- W3200667677 cites W2751352835 @default.
- W3200667677 cites W2775008495 @default.
- W3200667677 cites W2789621916 @default.
- W3200667677 cites W2795014519 @default.
- W3200667677 cites W2806146174 @default.
- W3200667677 cites W2888046743 @default.
- W3200667677 cites W2895826492 @default.
- W3200667677 cites W2900220985 @default.
- W3200667677 cites W2903854778 @default.
- W3200667677 cites W2911248861 @default.
- W3200667677 cites W2927874297 @default.
- W3200667677 cites W2934245145 @default.
- W3200667677 cites W2937386865 @default.
- W3200667677 cites W2939948226 @default.
- W3200667677 cites W2962352969 @default.
- W3200667677 cites W2964680034 @default.
- W3200667677 cites W2977367243 @default.
- W3200667677 cites W2978252541 @default.
- W3200667677 cites W2984194295 @default.
- W3200667677 cites W2990517669 @default.
- W3200667677 cites W2999407430 @default.
- W3200667677 cites W3000157665 @default.
- W3200667677 cites W3000554973 @default.
- W3200667677 cites W3019213887 @default.
- W3200667677 cites W3026035618 @default.