FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200668385> ?p ?o ?g. }

• W3200668385 endingPage "1786" @default.
• W3200668385 startingPage "1774" @default.
• W3200668385 abstract "Although most small B-cell lymphomas (SBCLs) can be diagnosed using routine methods, challenges exist. For example, marginal zone lymphomas (MZLs) can be difficult to rule-in, in large part because no widely-used, sensitive, and specific biomarker is available for the marginal zone cell of origin. In this study, it was hypothesized that DNA methylation array profiling can assist with the classification of SBCLs, including MZLs. Extramedullary SBCLs, including challenging cases, were reviewed internally for pathology consensus and profiled. By combining the resulting array data set with data sets from other groups, a set of 26 informative probes was selected and used to train machine learning models to classify 4 common SBCLs: chronic lymphocytic leukemia/small lymphocytic lymphoma, follicular lymphoma, mantle cell lymphoma, and MZL. Prediction probability cutoff was used to separate classifiable from unclassifiable cases, and show that the trained model was able to classify 95% of independent test cases (n = 264/279). The concordance between model predictions and pathology diagnoses was 99.6% (n = 262/263) among classifiable test cases. One validation reference test case was reclassified based on model prediction. The model was also used to predict the diagnoses of two challenging SBCLs. Although the differential examined and data on difficult cases are limited, these results support accurate methylation-based classification of SBCLs. Furthermore, high specificities of predictions suggest that methylation signatures can be used to rule-in MZLs." @default.
• W3200668385 created "2021-09-27" @default.
• W3200668385 creator A5005799713 @default.
• W3200668385 creator A5011254767 @default.
• W3200668385 creator A5021230262 @default.
• W3200668385 creator A5021559867 @default.
• W3200668385 creator A5036481473 @default.
• W3200668385 creator A5040987010 @default.
• W3200668385 creator A5065782582 @default.
• W3200668385 creator A5070959932 @default.
• W3200668385 creator A5072207500 @default.
• W3200668385 creator A5075737353 @default.
• W3200668385 creator A5077316921 @default.
• W3200668385 creator A5081888684 @default.
• W3200668385 date "2021-12-01" @default.
• W3200668385 modified "2023-10-18" @default.
• W3200668385 title "DNA Methylation-Based Classification of Small B-Cell Lymphomas" @default.
• W3200668385 cites W1656988592 @default.
• W3200668385 cites W1960763746 @default.
• W3200668385 cites W1975003408 @default.
• W3200668385 cites W2002497618 @default.
• W3200668385 cites W2029742174 @default.
• W3200668385 cites W2036142782 @default.
• W3200668385 cites W2051548222 @default.
• W3200668385 cites W2056040742 @default.
• W3200668385 cites W2063882823 @default.
• W3200668385 cites W2078025296 @default.
• W3200668385 cites W2079922362 @default.
• W3200668385 cites W2080690912 @default.
• W3200668385 cites W2086323499 @default.
• W3200668385 cites W2130852858 @default.
• W3200668385 cites W2143005970 @default.
• W3200668385 cites W2153250619 @default.
• W3200668385 cites W2507892764 @default.
• W3200668385 cites W2553488063 @default.
• W3200668385 cites W2580601263 @default.
• W3200668385 cites W2598133926 @default.
• W3200668385 cites W2787816121 @default.
• W3200668385 cites W2912236248 @default.
• W3200668385 cites W2953218432 @default.
• W3200668385 cites W2959585492 @default.
• W3200668385 cites W2975253127 @default.
• W3200668385 cites W2990223092 @default.
• W3200668385 cites W3024840842 @default.
• W3200668385 cites W3026078932 @default.
• W3200668385 cites W3097796274 @default.
• W3200668385 cites W3122927608 @default.
• W3200668385 doi "https://doi.org/10.1016/j.jmoldx.2021.09.002" @default.
• W3200668385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34562613" @default.
• W3200668385 hasPublicationYear "2021" @default.
• W3200668385 type Work @default.
• W3200668385 sameAs 3200668385 @default.
• W3200668385 citedByCount "0" @default.
• W3200668385 crossrefType "journal-article" @default.
• W3200668385 hasAuthorship W3200668385A5005799713 @default.
• W3200668385 hasAuthorship W3200668385A5011254767 @default.
• W3200668385 hasAuthorship W3200668385A5021230262 @default.
• W3200668385 hasAuthorship W3200668385A5021559867 @default.
• W3200668385 hasAuthorship W3200668385A5036481473 @default.
• W3200668385 hasAuthorship W3200668385A5040987010 @default.
• W3200668385 hasAuthorship W3200668385A5065782582 @default.
• W3200668385 hasAuthorship W3200668385A5070959932 @default.
• W3200668385 hasAuthorship W3200668385A5072207500 @default.
• W3200668385 hasAuthorship W3200668385A5075737353 @default.
• W3200668385 hasAuthorship W3200668385A5077316921 @default.
• W3200668385 hasAuthorship W3200668385A5081888684 @default.
• W3200668385 hasBestOaLocation W32006683851 @default.
• W3200668385 hasConcept C104317684 @default.
• W3200668385 hasConcept C142724271 @default.
• W3200668385 hasConcept C150194340 @default.
• W3200668385 hasConcept C160798450 @default.
• W3200668385 hasConcept C190727270 @default.
• W3200668385 hasConcept C203014093 @default.
• W3200668385 hasConcept C2777058707 @default.
• W3200668385 hasConcept C2777525834 @default.
• W3200668385 hasConcept C2777938653 @default.
• W3200668385 hasConcept C2778461978 @default.
• W3200668385 hasConcept C2779338263 @default.
• W3200668385 hasConcept C33288867 @default.
• W3200668385 hasConcept C41008148 @default.
• W3200668385 hasConcept C534262118 @default.
• W3200668385 hasConcept C54355233 @default.
• W3200668385 hasConcept C60644358 @default.
• W3200668385 hasConcept C70721500 @default.
• W3200668385 hasConcept C71924100 @default.
• W3200668385 hasConcept C86803240 @default.
• W3200668385 hasConceptScore W3200668385C104317684 @default.
• W3200668385 hasConceptScore W3200668385C142724271 @default.
• W3200668385 hasConceptScore W3200668385C150194340 @default.
• W3200668385 hasConceptScore W3200668385C160798450 @default.
• W3200668385 hasConceptScore W3200668385C190727270 @default.
• W3200668385 hasConceptScore W3200668385C203014093 @default.
• W3200668385 hasConceptScore W3200668385C2777058707 @default.
• W3200668385 hasConceptScore W3200668385C2777525834 @default.
• W3200668385 hasConceptScore W3200668385C2777938653 @default.
• W3200668385 hasConceptScore W3200668385C2778461978 @default.
• W3200668385 hasConceptScore W3200668385C2779338263 @default.
• W3200668385 hasConceptScore W3200668385C33288867 @default.

• next