Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200674328> ?p ?o ?g. }
- W3200674328 abstract "Abstract Fast-replicating neurotropic herpesviruses exemplified by herpes simplex virus-1 (HSV-1) naturally infect the central nervous system (CNS). However, most individuals intrinsically suppress the virus during a primary infection and preclude it from significantly damaging the CNS. Optineurin (OPTN) is a conserved autophagy receptor with little understanding of its role in neurotropic viral infections. We show that OPTN selectively targets HSV-1 tegument protein, VP16, and the fusion glycoprotein, gB, to degradation by autophagy. OPTN-deficient mice challenged with HSV-1 show significant cognitive decline and susceptibility to lethal CNS infection. OPTN deficiency unveils severe consequences for recruitment of adaptive immunity and suppression of neuronal necroptosis. Ocular HSV-1 infection is lethal without OPTN and is rescued using a necroptosis inhibitor. These results place OPTN at the crux of neuronal survival from potentially lethal CNS viral infections." @default.
- W3200674328 created "2021-09-27" @default.
- W3200674328 creator A5001474070 @default.
- W3200674328 creator A5010712444 @default.
- W3200674328 creator A5027530662 @default.
- W3200674328 creator A5041837926 @default.
- W3200674328 creator A5042265507 @default.
- W3200674328 creator A5068075547 @default.
- W3200674328 creator A5073584902 @default.
- W3200674328 creator A5076097951 @default.
- W3200674328 creator A5080023356 @default.
- W3200674328 creator A5081932918 @default.
- W3200674328 date "2021-09-13" @default.
- W3200674328 modified "2023-10-17" @default.
- W3200674328 title "OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection" @default.
- W3200674328 cites W1516223106 @default.
- W3200674328 cites W1963721982 @default.
- W3200674328 cites W1999732669 @default.
- W3200674328 cites W2005757378 @default.
- W3200674328 cites W2009225398 @default.
- W3200674328 cites W2013504579 @default.
- W3200674328 cites W2015438051 @default.
- W3200674328 cites W2048813950 @default.
- W3200674328 cites W2049279407 @default.
- W3200674328 cites W2062520454 @default.
- W3200674328 cites W2063506008 @default.
- W3200674328 cites W2075707505 @default.
- W3200674328 cites W2091041994 @default.
- W3200674328 cites W2103230459 @default.
- W3200674328 cites W2105014300 @default.
- W3200674328 cites W2138730204 @default.
- W3200674328 cites W2144531560 @default.
- W3200674328 cites W2154886355 @default.
- W3200674328 cites W2168198551 @default.
- W3200674328 cites W2169118703 @default.
- W3200674328 cites W2171998174 @default.
- W3200674328 cites W2323582440 @default.
- W3200674328 cites W2500850723 @default.
- W3200674328 cites W2516155426 @default.
- W3200674328 cites W2519070410 @default.
- W3200674328 cites W2584901479 @default.
- W3200674328 cites W2584906664 @default.
- W3200674328 cites W2592197441 @default.
- W3200674328 cites W2753239416 @default.
- W3200674328 cites W2809045422 @default.
- W3200674328 cites W2906835816 @default.
- W3200674328 cites W2963778214 @default.
- W3200674328 cites W2964736992 @default.
- W3200674328 cites W4231841295 @default.
- W3200674328 cites W4241869175 @default.
- W3200674328 cites W823356629 @default.
- W3200674328 doi "https://doi.org/10.1038/s41467-021-25642-z" @default.
- W3200674328 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8437952" @default.
- W3200674328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34518549" @default.
- W3200674328 hasPublicationYear "2021" @default.
- W3200674328 type Work @default.
- W3200674328 sameAs 3200674328 @default.
- W3200674328 citedByCount "23" @default.
- W3200674328 countsByYear W32006743282021 @default.
- W3200674328 countsByYear W32006743282022 @default.
- W3200674328 countsByYear W32006743282023 @default.
- W3200674328 crossrefType "journal-article" @default.
- W3200674328 hasAuthorship W3200674328A5001474070 @default.
- W3200674328 hasAuthorship W3200674328A5010712444 @default.
- W3200674328 hasAuthorship W3200674328A5027530662 @default.
- W3200674328 hasAuthorship W3200674328A5041837926 @default.
- W3200674328 hasAuthorship W3200674328A5042265507 @default.
- W3200674328 hasAuthorship W3200674328A5068075547 @default.
- W3200674328 hasAuthorship W3200674328A5073584902 @default.
- W3200674328 hasAuthorship W3200674328A5076097951 @default.
- W3200674328 hasAuthorship W3200674328A5080023356 @default.
- W3200674328 hasAuthorship W3200674328A5081932918 @default.
- W3200674328 hasBestOaLocation W32006743281 @default.
- W3200674328 hasConcept C159047783 @default.
- W3200674328 hasConcept C190283241 @default.
- W3200674328 hasConcept C203014093 @default.
- W3200674328 hasConcept C203522944 @default.
- W3200674328 hasConcept C22070199 @default.
- W3200674328 hasConcept C2522874641 @default.
- W3200674328 hasConcept C2776264772 @default.
- W3200674328 hasConcept C2776438120 @default.
- W3200674328 hasConcept C2777801377 @default.
- W3200674328 hasConcept C2778199166 @default.
- W3200674328 hasConcept C2778529815 @default.
- W3200674328 hasConcept C2781196997 @default.
- W3200674328 hasConcept C31573885 @default.
- W3200674328 hasConcept C54355233 @default.
- W3200674328 hasConcept C86803240 @default.
- W3200674328 hasConcept C94030615 @default.
- W3200674328 hasConceptScore W3200674328C159047783 @default.
- W3200674328 hasConceptScore W3200674328C190283241 @default.
- W3200674328 hasConceptScore W3200674328C203014093 @default.
- W3200674328 hasConceptScore W3200674328C203522944 @default.
- W3200674328 hasConceptScore W3200674328C22070199 @default.
- W3200674328 hasConceptScore W3200674328C2522874641 @default.
- W3200674328 hasConceptScore W3200674328C2776264772 @default.
- W3200674328 hasConceptScore W3200674328C2776438120 @default.
- W3200674328 hasConceptScore W3200674328C2777801377 @default.
- W3200674328 hasConceptScore W3200674328C2778199166 @default.
- W3200674328 hasConceptScore W3200674328C2778529815 @default.