Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200708519> ?p ?o ?g. }
- W3200708519 abstract "Cytochrome P450 enzymes (P450s, CYPs) catalyze the oxidative transformation of a wide range of organic substrates. Their functions are crucial to xenobiotic metabolism and steroid transformation in humans and other organisms. The enzymes are promising for synthetic biology applications but limited by several drawbacks including low turnover rates, poor stability, the dependance of expensive cofactors and redox partners, and the narrow substrate scope. To conquer these obstacles, emerging strategies including substrate engineering, usage of decoy and decoy-based small molecules auxiliaries, designing of artificial enzyme cascades and the incorporation of materials have been explored based on the unique properties of P450s. These strategies can be applied to a wide range of P450s and can be combined with protein engineering to improve the enzymatic activities. This minireview will focus on some recent developments of these strategies which have been used to leverage P450 catalysis. Remaining challenges and future opportunities will also be discussed." @default.
- W3200708519 created "2021-09-27" @default.
- W3200708519 creator A5006721750 @default.
- W3200708519 creator A5046225712 @default.
- W3200708519 date "2021-10-11" @default.
- W3200708519 modified "2023-10-16" @default.
- W3200708519 title "Harnessing P450 Enzyme for Biotechnology and Synthetic Biology" @default.
- W3200708519 cites W1963782724 @default.
- W3200708519 cites W1965061440 @default.
- W3200708519 cites W1969412813 @default.
- W3200708519 cites W1974181723 @default.
- W3200708519 cites W1978581033 @default.
- W3200708519 cites W1980231654 @default.
- W3200708519 cites W1981407107 @default.
- W3200708519 cites W1981824181 @default.
- W3200708519 cites W1985152937 @default.
- W3200708519 cites W1999227893 @default.
- W3200708519 cites W2000051743 @default.
- W3200708519 cites W2003756195 @default.
- W3200708519 cites W2009463903 @default.
- W3200708519 cites W2010427019 @default.
- W3200708519 cites W2010933326 @default.
- W3200708519 cites W2015242558 @default.
- W3200708519 cites W2016117607 @default.
- W3200708519 cites W2025263880 @default.
- W3200708519 cites W2026250319 @default.
- W3200708519 cites W2029728231 @default.
- W3200708519 cites W2042985281 @default.
- W3200708519 cites W2043349130 @default.
- W3200708519 cites W2048631970 @default.
- W3200708519 cites W2055130784 @default.
- W3200708519 cites W2062683863 @default.
- W3200708519 cites W2068422015 @default.
- W3200708519 cites W2072005992 @default.
- W3200708519 cites W2077621515 @default.
- W3200708519 cites W2081526839 @default.
- W3200708519 cites W2097930656 @default.
- W3200708519 cites W2105757566 @default.
- W3200708519 cites W2107782429 @default.
- W3200708519 cites W2108738397 @default.
- W3200708519 cites W2109826704 @default.
- W3200708519 cites W2118280926 @default.
- W3200708519 cites W2119223956 @default.
- W3200708519 cites W2119679161 @default.
- W3200708519 cites W2126748047 @default.
- W3200708519 cites W2152621767 @default.
- W3200708519 cites W2158741368 @default.
- W3200708519 cites W2160340330 @default.
- W3200708519 cites W2164873992 @default.
- W3200708519 cites W2169817148 @default.
- W3200708519 cites W2170832927 @default.
- W3200708519 cites W2215677265 @default.
- W3200708519 cites W2325137743 @default.
- W3200708519 cites W2325323555 @default.
- W3200708519 cites W2332608279 @default.
- W3200708519 cites W2333096653 @default.
- W3200708519 cites W2340271397 @default.
- W3200708519 cites W2416192302 @default.
- W3200708519 cites W2518144581 @default.
- W3200708519 cites W2564208922 @default.
- W3200708519 cites W2584690484 @default.
- W3200708519 cites W2588580023 @default.
- W3200708519 cites W2602060348 @default.
- W3200708519 cites W2618806840 @default.
- W3200708519 cites W2625250769 @default.
- W3200708519 cites W2750923976 @default.
- W3200708519 cites W2754369675 @default.
- W3200708519 cites W2765173544 @default.
- W3200708519 cites W2766726544 @default.
- W3200708519 cites W2767627070 @default.
- W3200708519 cites W2771599151 @default.
- W3200708519 cites W2773841172 @default.
- W3200708519 cites W2774839461 @default.
- W3200708519 cites W2779315858 @default.
- W3200708519 cites W2788775245 @default.
- W3200708519 cites W2793846302 @default.
- W3200708519 cites W2803451725 @default.
- W3200708519 cites W2803496635 @default.
- W3200708519 cites W2811069189 @default.
- W3200708519 cites W2824330570 @default.
- W3200708519 cites W2883893695 @default.
- W3200708519 cites W2886246311 @default.
- W3200708519 cites W2890909648 @default.
- W3200708519 cites W2898474497 @default.
- W3200708519 cites W2900583275 @default.
- W3200708519 cites W2905500176 @default.
- W3200708519 cites W2911868547 @default.
- W3200708519 cites W2914012452 @default.
- W3200708519 cites W2915943436 @default.
- W3200708519 cites W2930643972 @default.
- W3200708519 cites W2930647566 @default.
- W3200708519 cites W2932517300 @default.
- W3200708519 cites W2945094539 @default.
- W3200708519 cites W2961489606 @default.
- W3200708519 cites W2993040703 @default.
- W3200708519 cites W2996274551 @default.
- W3200708519 cites W3002831763 @default.
- W3200708519 cites W3006783522 @default.
- W3200708519 cites W3012749994 @default.
- W3200708519 cites W3023139418 @default.