FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200713369> ?p ?o ?g. }

• W3200713369 abstract "An authentic human liver model has the potential to be a revolutionary development in the field of biotechnology, and the progress of microtechnology has made this idea a reality. This technology enables the construction of micro-environments that can closely mimic the architecture and environment of human liver tissue in vivo, which is the key to building a physiologically relevant model. To this end, novel platforms have been produced with the goal of eventually building an authentic human liver model. A simple, single channel has been used for preliminary work with primary rat hepatocyte culture. Despite some successes, this system has shown several flaws, which include leakage and inconsistent viability. In order to rectify the leakage issue, a novel clamping system was devised, and cell culture tests have illustrated its capability and reliability in preventing leakage. Additionally, an initially open channel system was devised as an attempt to solve viability issues. We have also developed a novel dual channel system for co-culture of both types of liver cells, and initial tests are promising. This platform is capable of supporting this co-culture, although not consistently. Primary hepatocyte cultures in this system also led to an accidental discovery about the improved viability and cell contacts when cells are in tight confinement. Another important aspect in developing a liver model is obtaining physiologically relevant oxygen levels. To this end, oxygen diffusion simulations were constructed in COMSOL to determine the potential levels in the novel dual channel system. These results are promising and need to be validated through an oxygen fluorescence experiment. A perfusion system has been constructed for this experiment, and initial tests have been run to determine the proper amount of dye for an adequate fluorescent signal.%%%%M.S., Mechanical Engineering  – Drexel University, 2011" @default.
• W3200713369 created "2021-09-27" @default.
• W3200713369 creator A5075284244 @default.
• W3200713369 date "2021-07-16" @default.
• W3200713369 modified "2023-09-27" @default.
• W3200713369 title "Fundamental studies of liver cell culture microtechnology and techniques for the purpose of designing a liver model" @default.
• W3200713369 cites W1549122447 @default.
• W3200713369 cites W1848082114 @default.
• W3200713369 cites W1966681680 @default.
• W3200713369 cites W1969070480 @default.
• W3200713369 cites W1970857673 @default.
• W3200713369 cites W1972683398 @default.
• W3200713369 cites W1973963945 @default.
• W3200713369 cites W1989069505 @default.
• W3200713369 cites W2004875910 @default.
• W3200713369 cites W2006914719 @default.
• W3200713369 cites W2014134791 @default.
• W3200713369 cites W2018980642 @default.
• W3200713369 cites W2031896298 @default.
• W3200713369 cites W2048473946 @default.
• W3200713369 cites W2053473026 @default.
• W3200713369 cites W2061879595 @default.
• W3200713369 cites W2062651358 @default.
• W3200713369 cites W2069703095 @default.
• W3200713369 cites W2096474952 @default.
• W3200713369 cites W2103895990 @default.
• W3200713369 cites W2140835123 @default.
• W3200713369 cites W2157040356 @default.
• W3200713369 cites W2164548118 @default.
• W3200713369 cites W2171803108 @default.
• W3200713369 cites W2173366817 @default.
• W3200713369 cites W2489690826 @default.
• W3200713369 doi "https://doi.org/10.17918/etd-3877" @default.
• W3200713369 hasPublicationYear "2021" @default.
• W3200713369 type Work @default.
• W3200713369 sameAs 3200713369 @default.
• W3200713369 citedByCount "0" @default.
• W3200713369 crossrefType "dissertation" @default.
• W3200713369 hasAuthorship W3200713369A5075284244 @default.
• W3200713369 hasConcept C127413603 @default.
• W3200713369 hasConcept C171250308 @default.
• W3200713369 hasConcept C171874014 @default.
• W3200713369 hasConcept C192562407 @default.
• W3200713369 hasConcept C41008148 @default.
• W3200713369 hasConcept C70721500 @default.
• W3200713369 hasConcept C86803240 @default.
• W3200713369 hasConceptScore W3200713369C127413603 @default.
• W3200713369 hasConceptScore W3200713369C171250308 @default.
• W3200713369 hasConceptScore W3200713369C171874014 @default.
• W3200713369 hasConceptScore W3200713369C192562407 @default.
• W3200713369 hasConceptScore W3200713369C41008148 @default.
• W3200713369 hasConceptScore W3200713369C70721500 @default.
• W3200713369 hasConceptScore W3200713369C86803240 @default.
• W3200713369 hasLocation W32007133691 @default.
• W3200713369 hasOpenAccess W3200713369 @default.
• W3200713369 hasPrimaryLocation W32007133691 @default.
• W3200713369 hasRelatedWork W1549447689 @default.
• W3200713369 hasRelatedWork W1991264400 @default.
• W3200713369 hasRelatedWork W1996671578 @default.
• W3200713369 hasRelatedWork W2029750391 @default.
• W3200713369 hasRelatedWork W2045977772 @default.
• W3200713369 hasRelatedWork W2067586697 @default.
• W3200713369 hasRelatedWork W2562874990 @default.
• W3200713369 hasRelatedWork W2748952813 @default.
• W3200713369 hasRelatedWork W2899084033 @default.
• W3200713369 hasRelatedWork W4244050369 @default.
• W3200713369 isParatext "false" @default.
• W3200713369 isRetracted "false" @default.
• W3200713369 magId "3200713369" @default.
• W3200713369 workType "dissertation" @default.