FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200714544> ?p ?o ?g. }

• W3200714544 endingPage "101355" @default.
• W3200714544 startingPage "101355" @default.
• W3200714544 abstract "Monoamine oxidases (MAOs, including MAO-A and MAO-B) are essential deamination enzymes for neurotransmitters and other amines; thus, they are potential targets for treatment of mental disorders like depression and anxiety, and neurodegenerative disorders like Alzheimer's disease and Parkinson's disease. This study aimed at identifying MAOs inhibitory peptides from soybean protein hydrolysate through ultrafiltration purification and in silico prediction. Ultrafiltration fraction (0–3 kDa, SP-III) from soybean protein hydrolysate showed the highest inhibition activity with IC50 of 3.211 ± 0.125 mg/ml and 1.622 ± 0.025 mg/ml for MAO-A and MAO-B, respectively. Component 3 from SP-III gel filtration fraction exhibited the highest inhibitory activity with IC50 of 1.623 ± 0.150 mg/ml and 1.174 ± 0.111 mg/ml for MAO-A and MAO-B, respectively. Further affinity purified samples were sequenced by liquid chromatography tandem mass spectrometry and screened by HPEPDOCK. Eight peptides were selected for synthesis and evaluation. YSPYPQ displayed the highest MAO-A inhibitory activity with IC50 of 0.663 ± 0.091 mM, while PLYSN possessed the strongest MAO-B inhibition effect as IC50 of 0.204 ± 0.042 mM. Molecular docking revealed that their binding with MAOs might obstruct admission of substrate to the active sites. Current research confirmed that ultrafiltration purification and in silico prediction are effective to screen MAOs inhibitory peptides from soybean protein hydrolysate. The inhibitor peptides screened out here, especially PLYSN could be applied as potential functional nutraceuticals as MAOs inhibitor to treat neurodegenerative and mental disorders. Their application might suggest value of soybean as a routine and cheap source of neuromodulatory bioactive peptides." @default.
• W3200714544 created "2021-09-27" @default.
• W3200714544 creator A5051537826 @default.
• W3200714544 creator A5053789239 @default.
• W3200714544 creator A5082162741 @default.
• W3200714544 creator A5082774427 @default.
• W3200714544 creator A5086134325 @default.
• W3200714544 date "2021-12-01" @default.
• W3200714544 modified "2023-09-26" @default.
• W3200714544 title "Identification of monoamine oxidases inhibitory peptides from soybean protein hydrolysate through ultrafiltration purification and in silico studies" @default.
• W3200714544 cites W1579024202 @default.
• W3200714544 cites W1873799756 @default.
• W3200714544 cites W1975562146 @default.
• W3200714544 cites W2024770800 @default.
• W3200714544 cites W2042324920 @default.
• W3200714544 cites W2054253103 @default.
• W3200714544 cites W2060515720 @default.
• W3200714544 cites W2079154850 @default.
• W3200714544 cites W2092386772 @default.
• W3200714544 cites W2148169007 @default.
• W3200714544 cites W2314696933 @default.
• W3200714544 cites W2328979380 @default.
• W3200714544 cites W2507249427 @default.
• W3200714544 cites W2610398598 @default.
• W3200714544 cites W2739354616 @default.
• W3200714544 cites W2782078111 @default.
• W3200714544 cites W2797645136 @default.
• W3200714544 cites W2799876761 @default.
• W3200714544 cites W2802186587 @default.
• W3200714544 cites W2885286003 @default.
• W3200714544 cites W2889049588 @default.
• W3200714544 cites W2891695513 @default.
• W3200714544 cites W2901614104 @default.
• W3200714544 cites W2911833800 @default.
• W3200714544 cites W2912813506 @default.
• W3200714544 cites W2945669687 @default.
• W3200714544 cites W2946885747 @default.
• W3200714544 cites W2949204363 @default.
• W3200714544 cites W2954248861 @default.
• W3200714544 cites W2963164609 @default.
• W3200714544 cites W2967946137 @default.
• W3200714544 cites W2972368830 @default.
• W3200714544 cites W2991187333 @default.
• W3200714544 cites W2991218934 @default.
• W3200714544 cites W2999580270 @default.
• W3200714544 cites W3004861810 @default.
• W3200714544 cites W3010383207 @default.
• W3200714544 cites W3030498904 @default.
• W3200714544 cites W3030559350 @default.
• W3200714544 cites W3035793140 @default.
• W3200714544 cites W3047262488 @default.
• W3200714544 cites W3082467856 @default.
• W3200714544 cites W3083146307 @default.
• W3200714544 cites W3087036032 @default.
• W3200714544 cites W3100875504 @default.
• W3200714544 cites W3120960768 @default.
• W3200714544 doi "https://doi.org/10.1016/j.fbio.2021.101355" @default.
• W3200714544 hasPublicationYear "2021" @default.
• W3200714544 type Work @default.
• W3200714544 sameAs 3200714544 @default.
• W3200714544 citedByCount "8" @default.
• W3200714544 countsByYear W32007145442022 @default.
• W3200714544 countsByYear W32007145442023 @default.
• W3200714544 crossrefType "journal-article" @default.
• W3200714544 hasAuthorship W3200714544A5051537826 @default.
• W3200714544 hasAuthorship W3200714544A5053789239 @default.
• W3200714544 hasAuthorship W3200714544A5082162741 @default.
• W3200714544 hasAuthorship W3200714544A5082774427 @default.
• W3200714544 hasAuthorship W3200714544A5086134325 @default.
• W3200714544 hasConcept C104317684 @default.
• W3200714544 hasConcept C170493617 @default.
• W3200714544 hasConcept C181199279 @default.
• W3200714544 hasConcept C185592680 @default.
• W3200714544 hasConcept C187714386 @default.
• W3200714544 hasConcept C202751555 @default.
• W3200714544 hasConcept C2775864247 @default.
• W3200714544 hasConcept C2775905019 @default.
• W3200714544 hasConcept C2777752497 @default.
• W3200714544 hasConcept C2779281246 @default.
• W3200714544 hasConcept C28800991 @default.
• W3200714544 hasConcept C43617362 @default.
• W3200714544 hasConcept C50817676 @default.
• W3200714544 hasConcept C55493867 @default.
• W3200714544 hasConcept C94412978 @default.
• W3200714544 hasConceptScore W3200714544C104317684 @default.
• W3200714544 hasConceptScore W3200714544C170493617 @default.
• W3200714544 hasConceptScore W3200714544C181199279 @default.
• W3200714544 hasConceptScore W3200714544C185592680 @default.
• W3200714544 hasConceptScore W3200714544C187714386 @default.
• W3200714544 hasConceptScore W3200714544C202751555 @default.
• W3200714544 hasConceptScore W3200714544C2775864247 @default.
• W3200714544 hasConceptScore W3200714544C2775905019 @default.
• W3200714544 hasConceptScore W3200714544C2777752497 @default.
• W3200714544 hasConceptScore W3200714544C2779281246 @default.
• W3200714544 hasConceptScore W3200714544C28800991 @default.
• W3200714544 hasConceptScore W3200714544C43617362 @default.
• W3200714544 hasConceptScore W3200714544C50817676 @default.
• W3200714544 hasConceptScore W3200714544C55493867 @default.

• next