Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200718697> ?p ?o ?g. }
- W3200718697 endingPage "8557" @default.
- W3200718697 startingPage "8557" @default.
- W3200718697 abstract "Multiple sclerosis (MS) is common neurological disease of the central nervous system (CNS) affecting mostly young adults. Despite decades of studies, its etiology and pathogenesis are not fully unraveled and treatment is still insufficient. The vast majority of studies suggest that the immune system plays a major role in MS development. This is also supported by the effectiveness of currently available MS treatments that target immunocompetent cells. In this review, the role of antigen-presenting cells (APC) in MS development as well as the novel therapeutic options targeting those cells in MS are presented. It is known that in MS, peripheral self-antigen-specific immune cells are activated during antigen presentation process and they enter the CNS through the disrupted blood–brain barrier (BBB). Myelin-reactive CD4+ T-cells can be activated by dendritic cells, infiltrating macrophages, microglia cells, or B-cells, which all express MHC class II molecules. There are also suggestions that brain endothelial cells may act as non-professional APCs and present myelin-specific antigens with MHC class II. Similarly, astrocytes, the major glial cells in the CNS, were shown to act as non-professional APCs presenting myelin antigens to autoreactive T-cells. Several currently available MS drugs such as natalizumab, fingolimod, alemtuzumab, and ocrelizumab may modulate antigen presentation in MS. Another way to use this mechanism in MS treatment may be the usage of specific tolerogenic dendritic cells or the induction of tolerance to myelin antigens by peptide vaccines." @default.
- W3200718697 created "2021-09-27" @default.
- W3200718697 creator A5039570169 @default.
- W3200718697 creator A5043902100 @default.
- W3200718697 creator A5069514427 @default.
- W3200718697 date "2021-09-15" @default.
- W3200718697 modified "2023-09-30" @default.
- W3200718697 title "Targeting Antigen-Presenting Cells in Multiple Sclerosis Treatment" @default.
- W3200718697 cites W1491247658 @default.
- W3200718697 cites W1533029876 @default.
- W3200718697 cites W1554348880 @default.
- W3200718697 cites W1579942073 @default.
- W3200718697 cites W1610027395 @default.
- W3200718697 cites W1649418318 @default.
- W3200718697 cites W1667616536 @default.
- W3200718697 cites W1833759296 @default.
- W3200718697 cites W1907524553 @default.
- W3200718697 cites W1935519700 @default.
- W3200718697 cites W1953133353 @default.
- W3200718697 cites W1963675633 @default.
- W3200718697 cites W1963986494 @default.
- W3200718697 cites W1964662774 @default.
- W3200718697 cites W1970596945 @default.
- W3200718697 cites W1975104912 @default.
- W3200718697 cites W1978684572 @default.
- W3200718697 cites W1978790143 @default.
- W3200718697 cites W1981223333 @default.
- W3200718697 cites W1981621288 @default.
- W3200718697 cites W1982166883 @default.
- W3200718697 cites W1986173197 @default.
- W3200718697 cites W1989270381 @default.
- W3200718697 cites W1989688661 @default.
- W3200718697 cites W1991989670 @default.
- W3200718697 cites W1992480599 @default.
- W3200718697 cites W1993411699 @default.
- W3200718697 cites W1995644527 @default.
- W3200718697 cites W1996686270 @default.
- W3200718697 cites W1997209939 @default.
- W3200718697 cites W2000817149 @default.
- W3200718697 cites W2009662591 @default.
- W3200718697 cites W2010193242 @default.
- W3200718697 cites W2012177273 @default.
- W3200718697 cites W2022853021 @default.
- W3200718697 cites W2030830834 @default.
- W3200718697 cites W2031924346 @default.
- W3200718697 cites W2032300322 @default.
- W3200718697 cites W2034249407 @default.
- W3200718697 cites W2034990013 @default.
- W3200718697 cites W2038918914 @default.
- W3200718697 cites W2041904457 @default.
- W3200718697 cites W2042725832 @default.
- W3200718697 cites W2044022462 @default.
- W3200718697 cites W2044316391 @default.
- W3200718697 cites W2045820436 @default.
- W3200718697 cites W2047712629 @default.
- W3200718697 cites W2053313675 @default.
- W3200718697 cites W2054855625 @default.
- W3200718697 cites W2055926740 @default.
- W3200718697 cites W2056139117 @default.
- W3200718697 cites W2061374640 @default.
- W3200718697 cites W2064869298 @default.
- W3200718697 cites W2065745435 @default.
- W3200718697 cites W2066352983 @default.
- W3200718697 cites W2066978505 @default.
- W3200718697 cites W2067071374 @default.
- W3200718697 cites W2071159293 @default.
- W3200718697 cites W2075409284 @default.
- W3200718697 cites W2076692820 @default.
- W3200718697 cites W2081692629 @default.
- W3200718697 cites W2083565083 @default.
- W3200718697 cites W2085721994 @default.
- W3200718697 cites W2086547450 @default.
- W3200718697 cites W2089154573 @default.
- W3200718697 cites W2089617510 @default.
- W3200718697 cites W2091655047 @default.
- W3200718697 cites W2092733402 @default.
- W3200718697 cites W2092747941 @default.
- W3200718697 cites W2093009907 @default.
- W3200718697 cites W2095444837 @default.
- W3200718697 cites W2096618637 @default.
- W3200718697 cites W2097909514 @default.
- W3200718697 cites W2098588712 @default.
- W3200718697 cites W2098735224 @default.
- W3200718697 cites W2102237050 @default.
- W3200718697 cites W2104003910 @default.
- W3200718697 cites W2104595633 @default.
- W3200718697 cites W2105167551 @default.
- W3200718697 cites W2106467284 @default.
- W3200718697 cites W2108435419 @default.
- W3200718697 cites W2108793406 @default.
- W3200718697 cites W2111480581 @default.
- W3200718697 cites W2118282588 @default.
- W3200718697 cites W2118521277 @default.
- W3200718697 cites W2127716652 @default.
- W3200718697 cites W2130136130 @default.
- W3200718697 cites W2131036505 @default.
- W3200718697 cites W2134246923 @default.
- W3200718697 cites W2136266325 @default.