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- W3200719344 abstract "Today, it is well accepted that the quantitative measurement of anti-cancer drugs in human biological samples requires the development and validation of efficient bioanalytical methods. This study attempts to provide a high-capacity and thermo-sensitive nano-adsorbent for bicalutamide extraction from human biological fluids.In this study, five generations of thermo-sensitive dendrimers were synthesized onto the surface of WS2 nano-sheets. After drug-loading process from body fluids, the near-infrared (NIR) light (at 808 nm) was applied and light-to-heat conversion by the WS2 nano-sheets led to shrinkage in polymer chains, resulting the release of the entrapped drug. Finally, the extracted drug was analyzed via HPLC-UV system (at 270 nm). The final nano-adsorbent was described via FE-SEM, XRD, FT-IR, and TGA techniques. The adsorption isotherm data were well fitted by Langmuier isotherm model (R2 = 0.9978). The mean recoveries for spiking bicalutamide at three different concentrations in plasma and urine samples were 92.12% and 94.54% under the NIR light irradiation.We have developed a smart strategy to analyze bicalutamide in biological samples using near-infrared light irradiation in a controlled manner. All the results indicate the promising application of the proposed method for the extraction and determination of bicalutamide." @default.
- W3200719344 created "2021-09-27" @default.
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- W3200719344 date "2021-10-04" @default.
- W3200719344 modified "2023-10-14" @default.
- W3200719344 title "Near‐infrared light responsive dendrimers facilitate the extraction of bicalutamide from human plasma and urine" @default.
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- W3200719344 doi "https://doi.org/10.1002/biot.202100299" @default.
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