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• W3200719448 endingPage "171" @default.
• W3200719448 startingPage "164" @default.
• W3200719448 abstract "COVID-19 pandemic has been characterized by a pattern of consecutive declines and regrowth in European countries in 2020. After being partially regressed during the summer, the reappearance of the infection during fall 2020 in many temperate countries strongly suggests that temperature and cold may play a role in influencing the infectivity and virulence of SARS-CoV-2. While promoting medicine as an art, Hippocrates interpreted with logical reasoning the occurrence of diseases such as epidemics, as a consequence of environmental factors, in particular climatic variations. During the Renaissance, Sanctorius was one of the first to perform quantitative measurements, and Harvey discovered the circulation of blood by performing experimental procedures in animals. We think that a reasoning mixing various observations, measurements and experiments is fundamental to understand how cold increases infectivity and virulence of SARS-CoV-2. By this review, we provide evidence linking cold, angiotensin-II, vasoconstriction, hypoxia and aerobic glycolysis (the Warburg effect) to explain how cold affects the epidemiology of COVID-19. Also, a low humidity increases virus transmissibility, while a warm atmosphere, a moderate airway humidity, and the production of vasodilator angiotensin 1-7 by ACE2 are less favorable to the virus entry and/or its development. The meteorological and environmental parameters impacting COVID-19 pandemic should be reintegrated into a whole perspective by taking into account the different factors influencing transmissibility, infectivity and virulence of SARS-CoV-2. To understand the modern enigma represented by COVID-19, an interdisciplinary approach is surely essential." @default.
• W3200719448 created "2021-09-27" @default.
• W3200719448 creator A5015888633 @default.
• W3200719448 creator A5041420777 @default.
• W3200719448 creator A5048439546 @default.
• W3200719448 creator A5054966303 @default.
• W3200719448 creator A5078550481 @default.
• W3200719448 creator A5090230245 @default.
• W3200719448 date "2021-12-01" @default.
• W3200719448 modified "2023-09-27" @default.
• W3200719448 title "On the footsteps of Hippocrates, Sanctorius and Harvey to better understand the influence of cold on the occurrence of COVID-19 in European countries in 2020" @default.
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• W3200719448 doi "https://doi.org/10.1016/j.biochi.2021.09.009" @default.

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