FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200719710> ?p ?o ?g. }

• W3200719710 endingPage "2213" @default.
• W3200719710 startingPage "2205" @default.
• W3200719710 abstract "Hyperbaric oxygen treatment (HBOT) has been demonstrated to influence the keloid recurrence rate after surgery and to relieve keloid symptoms and other pathological processes in keloids. To explore the mechanism of the effect of HBOT on keloids, tumor immune gene expression and immune cell infiltration were studied in this work.From February 2021 to April 2021, HBOT was carried out on keloid patients four times before surgery. Keloid tissue samples were collected and divided into an HBOT group (keloid with HBOT before surgery [HK] group, n = 6) and a non-HBOT group (K group, n = 6). Tumor gene expression was analyzed with an Oncomine Immune Response Research Assay kit. Data were mined with R package. The differentially expressed genes between the groups were compared. Hub genes between the groups were determined and verified with Quantitative Real-time PCR. Immune cell infiltration was analyzed based on CIBERSORT deconvolution algorithm analysis of gene expression and verified with immunohistochemistry (IHC).Inflammatory cell infiltration was reduced in the HK group. There were 178 upregulated genes and 217 downregulated genes. Ten hub genes were identified, including Integrin Subunit Alpha M (ITGAM), interleukin (IL)-4, IL-6, IL-2, Protein Tyrosine Phosphatase Receptor Type C (PTPRC), CD86, transforming growth factor (TGF), CD80, CTLA4, and IL-10. CD80, ITGAM, IL-4, and PTPRC with significantly downregulated expression were identified. IL-10 and IL-2 were upregulated in the HK group but without a significant difference. Infiltration differences of CD8 lymphocyte T cells, CD4 lymphocyte T-activated memory cells, and dendritic resting cells were identified with gene CIBERSORT deconvolution algorithm analysis. Infiltration levels of CD4 lymphocyte T cell in the HK group were significantly higher than those of the K group in IHC verification.HBOT affected tumor gene expression and immune cell infiltration in keloids. CD4 lymphocyte T cell, especially activated memory CD4+T, might be the key regulatory immune cell, and its related gene expression needs further study." @default.
• W3200719710 created "2021-09-27" @default.
• W3200719710 creator A5005514913 @default.
• W3200719710 creator A5013745575 @default.
• W3200719710 creator A5022985898 @default.
• W3200719710 creator A5023049133 @default.
• W3200719710 creator A5030334248 @default.
• W3200719710 creator A5036016529 @default.
• W3200719710 creator A5072038986 @default.
• W3200719710 creator A5074055611 @default.
• W3200719710 creator A5074102139 @default.
• W3200719710 creator A5077592719 @default.
• W3200719710 creator A5086930817 @default.
• W3200719710 date "2021-09-13" @default.
• W3200719710 modified "2023-09-26" @default.
• W3200719710 title "Hyperbaric oxygen treatment on keloid tumor immune gene expression" @default.
• W3200719710 cites W1975951635 @default.
• W3200719710 cites W2018544300 @default.
• W3200719710 cites W2032233211 @default.
• W3200719710 cites W2037922623 @default.
• W3200719710 cites W2067399742 @default.
• W3200719710 cites W2086706655 @default.
• W3200719710 cites W2094171424 @default.
• W3200719710 cites W2145901814 @default.
• W3200719710 cites W2152624886 @default.
• W3200719710 cites W2153616177 @default.
• W3200719710 cites W2161423477 @default.
• W3200719710 cites W2593918601 @default.
• W3200719710 cites W2765863444 @default.
• W3200719710 cites W2771195136 @default.
• W3200719710 cites W2883392486 @default.
• W3200719710 cites W2883554039 @default.
• W3200719710 cites W2903038739 @default.
• W3200719710 cites W2917410143 @default.
• W3200719710 cites W2922886236 @default.
• W3200719710 cites W2971635939 @default.
• W3200719710 cites W2989620718 @default.
• W3200719710 cites W3108729041 @default.
• W3200719710 cites W3112440775 @default.
• W3200719710 doi "https://doi.org/10.1097/cm9.0000000000001780" @default.
• W3200719710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8478393" @default.
• W3200719710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34553702" @default.
• W3200719710 hasPublicationYear "2021" @default.
• W3200719710 type Work @default.
• W3200719710 sameAs 3200719710 @default.
• W3200719710 citedByCount "12" @default.
• W3200719710 countsByYear W32007197102022 @default.
• W3200719710 countsByYear W32007197102023 @default.
• W3200719710 crossrefType "journal-article" @default.
• W3200719710 hasAuthorship W3200719710A5005514913 @default.
• W3200719710 hasAuthorship W3200719710A5013745575 @default.
• W3200719710 hasAuthorship W3200719710A5022985898 @default.
• W3200719710 hasAuthorship W3200719710A5023049133 @default.
• W3200719710 hasAuthorship W3200719710A5030334248 @default.
• W3200719710 hasAuthorship W3200719710A5036016529 @default.
• W3200719710 hasAuthorship W3200719710A5072038986 @default.
• W3200719710 hasAuthorship W3200719710A5074055611 @default.
• W3200719710 hasAuthorship W3200719710A5074102139 @default.
• W3200719710 hasAuthorship W3200719710A5077592719 @default.
• W3200719710 hasAuthorship W3200719710A5086930817 @default.
• W3200719710 hasBestOaLocation W32007197101 @default.
• W3200719710 hasConcept C104317684 @default.
• W3200719710 hasConcept C142724271 @default.
• W3200719710 hasConcept C150194340 @default.
• W3200719710 hasConcept C154317977 @default.
• W3200719710 hasConcept C167672396 @default.
• W3200719710 hasConcept C202751555 @default.
• W3200719710 hasConcept C203014093 @default.
• W3200719710 hasConcept C204232928 @default.
• W3200719710 hasConcept C2777538232 @default.
• W3200719710 hasConcept C2778297628 @default.
• W3200719710 hasConcept C39347974 @default.
• W3200719710 hasConcept C502942594 @default.
• W3200719710 hasConcept C55493867 @default.
• W3200719710 hasConcept C71924100 @default.
• W3200719710 hasConcept C86803240 @default.
• W3200719710 hasConcept C8891405 @default.
• W3200719710 hasConceptScore W3200719710C104317684 @default.
• W3200719710 hasConceptScore W3200719710C142724271 @default.
• W3200719710 hasConceptScore W3200719710C150194340 @default.
• W3200719710 hasConceptScore W3200719710C154317977 @default.
• W3200719710 hasConceptScore W3200719710C167672396 @default.
• W3200719710 hasConceptScore W3200719710C202751555 @default.
• W3200719710 hasConceptScore W3200719710C203014093 @default.
• W3200719710 hasConceptScore W3200719710C204232928 @default.
• W3200719710 hasConceptScore W3200719710C2777538232 @default.
• W3200719710 hasConceptScore W3200719710C2778297628 @default.
• W3200719710 hasConceptScore W3200719710C39347974 @default.
• W3200719710 hasConceptScore W3200719710C502942594 @default.
• W3200719710 hasConceptScore W3200719710C55493867 @default.
• W3200719710 hasConceptScore W3200719710C71924100 @default.
• W3200719710 hasConceptScore W3200719710C86803240 @default.
• W3200719710 hasConceptScore W3200719710C8891405 @default.
• W3200719710 hasIssue "18" @default.
• W3200719710 hasLocation W32007197101 @default.
• W3200719710 hasLocation W32007197102 @default.
• W3200719710 hasLocation W32007197103 @default.
• W3200719710 hasLocation W32007197104 @default.

• next