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- W3200722040 abstract "For several decades, cytotoxic chemotherapy was the mainstay of treatment for pancreatic ductal adenocarcinoma (PDAC). Advances in molecular profiling have identified predictive genomic alterations in PDAC-the germline and somatic genome are now routinely interrogated in patients with PDAC because of their therapeutic relevance. The composite role of the epithelial cell compartment and the tumor microenvironment in defining PDAC biology needs further elucidation to deconvolute the spatiotemporal heterogeneity appreciated in this disease. Novel clinical trial approaches leveraging signal seeking, adaptive statistical designs, and master protocols using several candidate drugs that target relevant therapeutic targets are are essential to unlocking the potential of precision medicine in PDAC." @default.
- W3200722040 created "2021-09-27" @default.
- W3200722040 creator A5083509294 @default.
- W3200722040 date "2021-10-01" @default.
- W3200722040 modified "2023-09-27" @default.
- W3200722040 title "Precision Medicine and Pancreatic Cancer" @default.
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- W3200722040 doi "https://doi.org/10.1016/j.soc.2021.06.008" @default.
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