Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200727880> ?p ?o ?g. }
- W3200727880 endingPage "100350" @default.
- W3200727880 startingPage "100350" @default.
- W3200727880 abstract "Mitochondria play an important role in the synthesis of steroid hormones, including the sex hormone estrogen. Sex-specific regulation of these hormones is important for phenotypic development and downstream, sex-specific activational effects in both brain and behavior. First, mitochondrial contribution to the synthesis of estrogen, followed by a discussion of the signaling interactions between estrogen and the mitochondria will be reviewed. Next, disorders with an established sex difference related to aging, mood, and cognition will be examined. Finally, review of mitochondria as a biomarker of disease and data supporting efforts in targeting mitochondria as a therapeutic target for the amelioration of these disorders will be discussed. Taken together, this review aims to assess the influence of E2 on mitochondrial function within the brain via exploration of E2-ER interactions within neural mitochondria and how they may act to influence the development and presentation of neurodegenerative and neurocognitive diseases with known sex differences." @default.
- W3200727880 created "2021-09-27" @default.
- W3200727880 creator A5048925804 @default.
- W3200727880 date "2021-12-01" @default.
- W3200727880 modified "2023-10-16" @default.
- W3200727880 title "Mitochondria as the target for disease related hormonal dysregulation" @default.
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