FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200728521> ?p ?o ?g. }

• W3200728521 endingPage "148" @default.
• W3200728521 startingPage "135" @default.
• W3200728521 abstract "The family of voltage-gated potassium Kv2 channels consists of the Kv2.1 and Kv2.2 subtypes. Kv2.1 is constitutively highly phosphorylated in neurons and its function relies on its phosphorylation state. Whether the function of Kv2.2 is also dependent on its phosphorylation state remains unknown. Here, we investigated whether Kv2.2 channels can be phosphorylated by protein kinase C (PKC) and examined the effects of PKC-induced phosphorylation on their activity and function. Activation of PKC inhibited Kv2.2 currents and altered their steady-state activation in HEK293 cells. Point mutations and specific antibodies against phosphorylated S481 or S488 demonstrated the importance of these residues for the PKC-dependent modulation of Kv2.2. In layer II pyramidal neurons in cortical slices, activation of PKC similarly regulated native Kv2.2 channels and simultaneously reduced the frequency of action potentials. In conclusion, this study provides the first evidence to our knowledge that PKC-induced phosphorylation of the Kv2.2 channel controls the excitability of cortical pyramidal neurons." @default.
• W3200728521 created "2021-09-27" @default.
• W3200728521 creator A5002192443 @default.
• W3200728521 creator A5051439492 @default.
• W3200728521 creator A5056016532 @default.
• W3200728521 creator A5061189341 @default.
• W3200728521 creator A5065475036 @default.
• W3200728521 creator A5087238533 @default.
• W3200728521 date "2021-09-20" @default.
• W3200728521 modified "2023-10-16" @default.
• W3200728521 title "Protein Kinase C Controls the Excitability of Cortical Pyramidal Neurons by Regulating Kv2.2 Channel Activity" @default.
• W3200728521 cites W1565904295 @default.
• W3200728521 cites W1576671418 @default.
• W3200728521 cites W1580819952 @default.
• W3200728521 cites W1937739983 @default.
• W3200728521 cites W1970000366 @default.
• W3200728521 cites W1970891910 @default.
• W3200728521 cites W1982715379 @default.
• W3200728521 cites W1985864666 @default.
• W3200728521 cites W1992969978 @default.
• W3200728521 cites W1996589818 @default.
• W3200728521 cites W1999701371 @default.
• W3200728521 cites W2009181911 @default.
• W3200728521 cites W2009271710 @default.
• W3200728521 cites W2013631564 @default.
• W3200728521 cites W2027438631 @default.
• W3200728521 cites W2027980594 @default.
• W3200728521 cites W2029194434 @default.
• W3200728521 cites W2031426087 @default.
• W3200728521 cites W2039759444 @default.
• W3200728521 cites W2043225986 @default.
• W3200728521 cites W2044349535 @default.
• W3200728521 cites W2046025111 @default.
• W3200728521 cites W2055121607 @default.
• W3200728521 cites W2063256813 @default.
• W3200728521 cites W2071651200 @default.
• W3200728521 cites W2075636379 @default.
• W3200728521 cites W2086684841 @default.
• W3200728521 cites W2092616569 @default.
• W3200728521 cites W2099949778 @default.
• W3200728521 cites W2107280592 @default.
• W3200728521 cites W2118185015 @default.
• W3200728521 cites W2123347941 @default.
• W3200728521 cites W2140875370 @default.
• W3200728521 cites W2145548823 @default.
• W3200728521 cites W2151942667 @default.
• W3200728521 cites W2155467489 @default.
• W3200728521 cites W2157952220 @default.
• W3200728521 cites W2168386087 @default.
• W3200728521 cites W2172067396 @default.
• W3200728521 cites W2277356999 @default.
• W3200728521 cites W2331686197 @default.
• W3200728521 cites W2340166006 @default.
• W3200728521 cites W2407132535 @default.
• W3200728521 cites W2545707878 @default.
• W3200728521 cites W2592534393 @default.
• W3200728521 cites W2612474029 @default.
• W3200728521 cites W2626777690 @default.
• W3200728521 cites W2770496860 @default.
• W3200728521 cites W2972361058 @default.
• W3200728521 cites W4245660285 @default.
• W3200728521 doi "https://doi.org/10.1007/s12264-021-00773-x" @default.
• W3200728521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34542799" @default.
• W3200728521 hasPublicationYear "2021" @default.
• W3200728521 type Work @default.
• W3200728521 sameAs 3200728521 @default.
• W3200728521 citedByCount "3" @default.
• W3200728521 countsByYear W32007285212022 @default.
• W3200728521 countsByYear W32007285212023 @default.
• W3200728521 crossrefType "journal-article" @default.
• W3200728521 hasAuthorship W3200728521A5002192443 @default.
• W3200728521 hasAuthorship W3200728521A5051439492 @default.
• W3200728521 hasAuthorship W3200728521A5056016532 @default.
• W3200728521 hasAuthorship W3200728521A5061189341 @default.
• W3200728521 hasAuthorship W3200728521A5065475036 @default.
• W3200728521 hasAuthorship W3200728521A5087238533 @default.
• W3200728521 hasBestOaLocation W32007285212 @default.
• W3200728521 hasConcept C11960822 @default.
• W3200728521 hasConcept C12554922 @default.
• W3200728521 hasConcept C169760540 @default.
• W3200728521 hasConcept C184235292 @default.
• W3200728521 hasConcept C185592680 @default.
• W3200728521 hasConcept C195794163 @default.
• W3200728521 hasConcept C83743174 @default.
• W3200728521 hasConcept C86803240 @default.
• W3200728521 hasConcept C95444343 @default.
• W3200728521 hasConcept C97029542 @default.
• W3200728521 hasConceptScore W3200728521C11960822 @default.
• W3200728521 hasConceptScore W3200728521C12554922 @default.
• W3200728521 hasConceptScore W3200728521C169760540 @default.
• W3200728521 hasConceptScore W3200728521C184235292 @default.
• W3200728521 hasConceptScore W3200728521C185592680 @default.
• W3200728521 hasConceptScore W3200728521C195794163 @default.
• W3200728521 hasConceptScore W3200728521C83743174 @default.
• W3200728521 hasConceptScore W3200728521C86803240 @default.
• W3200728521 hasConceptScore W3200728521C95444343 @default.
• W3200728521 hasConceptScore W3200728521C97029542 @default.
• W3200728521 hasIssue "2" @default.

• next