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• W3200737647 abstract "Cardiovascular diseases (CVD) are the most important cause of morbidity and mortality in patients with T1D. Children with T1D had similar or higher prevalence of being overweight or obese compared to their healthy peers. In this study we aimed to determine prevalence of CVD risk factors in children and adolescents with T1D and the impact of obesity and sex differences on these factors.Data of 365 patients (200 girls, 165 boys) who were 10-21 years of age and who had been using intensive insulin therapy with a diagnosis of T1D for at least 3 years were evaluated. Patients were divided into normal weight (NW), overweight (OW) and obese (Ob) groups according to body mass index percentiles. Risk factors for CVD (obesity, dyslipidemia, hypertension) were compared between groups, and impact of gender was also analyzed.Prevalence of OW/Ob was 25.9% which was significantly higher in girls (30.6% vs 20.1%, p<0.001). Rate of hypertension was highest in OW/Ob girls followed by OW/Ob boys, and similar in NW girls and boys (p=0.003). Mean LDL-c and TG levels were highest in OW/Ob girls, followed by OW/Ob boys, NW girls and NW boys, respectively (p<0.001 and p<0.001, respectively). Mean HDL-c levels were similar among groups. Rates of high LDL-c and TG were similar between OW/Ob girls and boys and higher than NW girls, followed by NW boys (p<0.001 and p<0.001, respectively). Rate of low HDL-c was similar in OW/Ob girls and boys, and higher than NW girls, followed by NW boys (p<0.001). Overall, girls were 1.9 times more likely than boys to have two or more risk factors for CVD. Factors associated with risk for CVD in multiple logistic regression analyses were being a girl, followed by higher daily insulin dose, higher HbA1c, longer diabetes duration (r=0.856; p<0.001).In spite of the increased prevalence for obesity in both sexes, the trend for CVD risk factors has increased more in obese girls, followed by obese boys and girls who are normal weight. Girls with T1D are more likely to be overweight/obese and to have CVD risk than boys, highlighting the need for early intervention and additional studies to elucidate the causes, particularly in girls with T1D." @default.
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• W3200737647 date "2023-08-10" @default.
• W3200737647 modified "2023-09-28" @default.
• W3200737647 title "Cardiovascular Risk Factors in Adolescents with Type 1 Diabetes: Prevalence and Gender Differences" @default.
• W3200737647 doi "https://doi.org/10.4274/jcrpe.galenos.2023.2023-12-12" @default.
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