Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200744241> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3200744241 endingPage "94" @default.
- W3200744241 startingPage "86" @default.
- W3200744241 abstract "Comorbidity is a common condition in medical practice. The presence of comorbid conditions in a patient makes a great contribution to the course and prognosis of the underlying disease, as well as the development of complications [12]. At the same time, diseases occurring with broncho-obstructive syndrome and arterial hypertension syndrome are widespread throughout the world [13, 14]. The aim of this study was to assess the degree of endothelial dysfunction associated with impaired nitric oxide synthesis, based on the state of the NO/NOS/ADMA system and genetic polymorphisms of the nitric oxide synthetase gene in patients with bronchial asthma combined with essential hypertension. Materials and methods Three groups of patients, 96 people each, were formed, corresponding in age and gender structure with a diagnosis of bronchial asthma (BA group), essential hypertension (EH group) and their joint course (BA+EH group). Serum concentrations of asymmetric dimethylarginine, symmetric dimethylarginine, genetic polymorphisms of nitric oxide synthase (synthases NOS3 786T/C and NOS3 894G/T) were determined. To determine the role of other factors in increasing the concentration of ADMA and SDMA, multiple linear regression analysis was performed. Results: according to the results of the study, for a group of patients with a combination of bronchial asthma and hypertension, there are increased levels of ADMA and SDMA, the T allele NOS3 786C/T is more common in hypertension, in multiple linear regression significant factors in increasing ADMA are the presence of hypertension, bronchial asthma, body mass index and glomerular filtration rate, for SDMA - the presence of hypertension, asthma and glomerular filtration rate. Conclusions: The comorbidity of bronchial asthma and arterial hypertension is associated with an increased serum concentration of ADMA and SDMA. The presence of the TT genotype of the NOS3 786C/T polymorphism is associated with an increased incidence of arterial hypertension in patients with asthma." @default.
- W3200744241 created "2021-09-27" @default.
- W3200744241 creator A5015688174 @default.
- W3200744241 creator A5037851318 @default.
- W3200744241 creator A5052360349 @default.
- W3200744241 creator A5087081873 @default.
- W3200744241 date "2021-07-30" @default.
- W3200744241 modified "2023-09-27" @default.
- W3200744241 title "THE STATE OF THE NITRIC OXIDE SYNTHESIS SYSTEM IN THE COMORBID COURSE OF BRONCHIAL ASTHMA AND HYPERTENSION" @default.
- W3200744241 doi "https://doi.org/10.26787/nydha-2686-6838-2021-23-7-86-94" @default.
- W3200744241 hasPublicationYear "2021" @default.
- W3200744241 type Work @default.
- W3200744241 sameAs 3200744241 @default.
- W3200744241 citedByCount "0" @default.
- W3200744241 crossrefType "journal-article" @default.
- W3200744241 hasAuthorship W3200744241A5015688174 @default.
- W3200744241 hasAuthorship W3200744241A5037851318 @default.
- W3200744241 hasAuthorship W3200744241A5052360349 @default.
- W3200744241 hasAuthorship W3200744241A5087081873 @default.
- W3200744241 hasConcept C126322002 @default.
- W3200744241 hasConcept C164705383 @default.
- W3200744241 hasConcept C185592680 @default.
- W3200744241 hasConcept C2776042228 @default.
- W3200744241 hasConcept C2777097880 @default.
- W3200744241 hasConcept C2777468819 @default.
- W3200744241 hasConcept C2777622882 @default.
- W3200744241 hasConcept C2779159551 @default.
- W3200744241 hasConcept C2779877776 @default.
- W3200744241 hasConcept C2780221984 @default.
- W3200744241 hasConcept C2780972559 @default.
- W3200744241 hasConcept C515207424 @default.
- W3200744241 hasConcept C519581460 @default.
- W3200744241 hasConcept C55493867 @default.
- W3200744241 hasConcept C71924100 @default.
- W3200744241 hasConcept C84393581 @default.
- W3200744241 hasConcept C90924648 @default.
- W3200744241 hasConceptScore W3200744241C126322002 @default.
- W3200744241 hasConceptScore W3200744241C164705383 @default.
- W3200744241 hasConceptScore W3200744241C185592680 @default.
- W3200744241 hasConceptScore W3200744241C2776042228 @default.
- W3200744241 hasConceptScore W3200744241C2777097880 @default.
- W3200744241 hasConceptScore W3200744241C2777468819 @default.
- W3200744241 hasConceptScore W3200744241C2777622882 @default.
- W3200744241 hasConceptScore W3200744241C2779159551 @default.
- W3200744241 hasConceptScore W3200744241C2779877776 @default.
- W3200744241 hasConceptScore W3200744241C2780221984 @default.
- W3200744241 hasConceptScore W3200744241C2780972559 @default.
- W3200744241 hasConceptScore W3200744241C515207424 @default.
- W3200744241 hasConceptScore W3200744241C519581460 @default.
- W3200744241 hasConceptScore W3200744241C55493867 @default.
- W3200744241 hasConceptScore W3200744241C71924100 @default.
- W3200744241 hasConceptScore W3200744241C84393581 @default.
- W3200744241 hasConceptScore W3200744241C90924648 @default.
- W3200744241 hasLocation W32007442411 @default.
- W3200744241 hasOpenAccess W3200744241 @default.
- W3200744241 hasPrimaryLocation W32007442411 @default.
- W3200744241 hasRelatedWork W1982818528 @default.
- W3200744241 hasRelatedWork W2015814983 @default.
- W3200744241 hasRelatedWork W2073124845 @default.
- W3200744241 hasRelatedWork W2095483432 @default.
- W3200744241 hasRelatedWork W2107818859 @default.
- W3200744241 hasRelatedWork W2153125904 @default.
- W3200744241 hasRelatedWork W2377870889 @default.
- W3200744241 hasRelatedWork W2380540567 @default.
- W3200744241 hasRelatedWork W2749999767 @default.
- W3200744241 hasRelatedWork W2773449050 @default.
- W3200744241 isParatext "false" @default.
- W3200744241 isRetracted "false" @default.
- W3200744241 magId "3200744241" @default.
- W3200744241 workType "article" @default.