Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200748162> ?p ?o ?g. }
- W3200748162 abstract "Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) plays essential roles in the proliferation of skeletal muscle satellite cells (MuSCs). Increasing evidence has shown that IGF2BP1 regulates the expression of noncoding RNAs and mRNAs. However, the related molecular network remains to be fully understood. Therefore, we performed RNA sequencing and analyzed the microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and mRNAs differentially expressed in goat MuSCs treated with IGF2BP1 overexpressing and empty vectors. A total of 36 miRNAs, 59 lncRNAs, and 44 mRNAs were differentially expressed caused by IGF2BP1. Expectedly, they were enriched in muscle development-related Rap1, PI3K-AKT, and FoxO signaling pathways. Finally, we constructed a lncRNA-miRNA-mRNA interaction network containing 30 lncRNAs, 15 miRNAs, and 34 mRNAs, in which several miRNAs, including miR-133a-3p, miR-204-5p, miR-125a-3p, miR-145-3p, and miR-423-5p, relate with cell growth and participate in muscle development. Overall, we constructed an IGF2BP1-related network, which provides new insight into the myogenic proliferation of goat." @default.
- W3200748162 created "2021-09-27" @default.
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- W3200748162 date "2021-01-01" @default.
- W3200748162 modified "2023-10-17" @default.
- W3200748162 title "Identification of IGF2BP1 ‐related lncRNA‐miRNA‐mRNA network in goat skeletal muscle satellite cells" @default.
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- W3200748162 doi "https://doi.org/10.1111/asj.13631" @default.
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