Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200750802> ?p ?o ?g. }
- W3200750802 endingPage "4805" @default.
- W3200750802 startingPage "4794" @default.
- W3200750802 abstract "Poly(ADP-ribose) polymerase 1 (PARP1) is a key mediator of various forms of DNA damage repair and plays an important role in the progression of several cancer types. The enzyme is activated by binding to DNA single-strand and double-strand breaks. Its contribution to chromatin remodeling makes PARP1 crucial for gene expression regulation. Inhibition of its activity with small molecules leads to the synthetic lethal effect by impeding DNA repair in the treatment of cancer cells. At first, PARP1 inhibitors (PARPis) were developed to target breast cancer mutated cancer cells. Currently, PARPis are being studied to be used in a broader variety of patients either as single agents or in combination with chemotherapy, antiangiogenic agents, ionizing radiation, and immune checkpoint inhibitors. Ongoing clinical trials on olaparib, rucaparib, niraparib, veliparib, and the recent talazoparib show the advantage of these agents in overcoming PARPi resistance and underline their efficacy in targeted treatment of several hematologic malignancies. In this review, focusing on the crucial role of PARP1 in physiological and pathological effects in myelodysplastic syndrome and acute myeloid leukemia, we give an outline of the enzyme's mechanisms of action and its role in the pathophysiology and prognosis of myelodysplastic syndrome/acute myeloid leukemia and we analyze the available data on the use of PARPis, highlighting their promising advances in clinical application." @default.
- W3200750802 created "2021-09-27" @default.
- W3200750802 creator A5019372427 @default.
- W3200750802 creator A5025768647 @default.
- W3200750802 creator A5037250948 @default.
- W3200750802 creator A5038750676 @default.
- W3200750802 creator A5088890021 @default.
- W3200750802 date "2021-11-23" @default.
- W3200750802 modified "2023-10-14" @default.
- W3200750802 title "PARP1 as a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome" @default.
- W3200750802 cites W1255676896 @default.
- W3200750802 cites W1523531555 @default.
- W3200750802 cites W1535695103 @default.
- W3200750802 cites W1959879209 @default.
- W3200750802 cites W1962616116 @default.
- W3200750802 cites W1965006127 @default.
- W3200750802 cites W1965741507 @default.
- W3200750802 cites W1969913973 @default.
- W3200750802 cites W1970184435 @default.
- W3200750802 cites W1970211011 @default.
- W3200750802 cites W1970435786 @default.
- W3200750802 cites W1973268287 @default.
- W3200750802 cites W1978595257 @default.
- W3200750802 cites W1980904297 @default.
- W3200750802 cites W1984924974 @default.
- W3200750802 cites W1989714107 @default.
- W3200750802 cites W1992397774 @default.
- W3200750802 cites W1995733047 @default.
- W3200750802 cites W2009007206 @default.
- W3200750802 cites W2012434765 @default.
- W3200750802 cites W2021588881 @default.
- W3200750802 cites W2027236982 @default.
- W3200750802 cites W2030592870 @default.
- W3200750802 cites W2033004300 @default.
- W3200750802 cites W2042685981 @default.
- W3200750802 cites W2048811029 @default.
- W3200750802 cites W2049028195 @default.
- W3200750802 cites W2050086663 @default.
- W3200750802 cites W2055611673 @default.
- W3200750802 cites W2056927568 @default.
- W3200750802 cites W2059861896 @default.
- W3200750802 cites W2060321052 @default.
- W3200750802 cites W2061020520 @default.
- W3200750802 cites W2082932840 @default.
- W3200750802 cites W2098737737 @default.
- W3200750802 cites W2108979163 @default.
- W3200750802 cites W2111437716 @default.
- W3200750802 cites W2116804853 @default.
- W3200750802 cites W2117049355 @default.
- W3200750802 cites W2117513720 @default.
- W3200750802 cites W2117547022 @default.
- W3200750802 cites W2118211359 @default.
- W3200750802 cites W2118542406 @default.
- W3200750802 cites W2122205071 @default.
- W3200750802 cites W2124037827 @default.
- W3200750802 cites W2130078242 @default.
- W3200750802 cites W2151213561 @default.
- W3200750802 cites W2165041092 @default.
- W3200750802 cites W2166071408 @default.
- W3200750802 cites W2169703537 @default.
- W3200750802 cites W2172297296 @default.
- W3200750802 cites W2173261030 @default.
- W3200750802 cites W2181166720 @default.
- W3200750802 cites W2194177867 @default.
- W3200750802 cites W2291307173 @default.
- W3200750802 cites W2296857019 @default.
- W3200750802 cites W2399338035 @default.
- W3200750802 cites W2441107086 @default.
- W3200750802 cites W2492297278 @default.
- W3200750802 cites W2499799649 @default.
- W3200750802 cites W2511764688 @default.
- W3200750802 cites W2516721096 @default.
- W3200750802 cites W2530874742 @default.
- W3200750802 cites W2557666746 @default.
- W3200750802 cites W2561691429 @default.
- W3200750802 cites W2565560602 @default.
- W3200750802 cites W2575375384 @default.
- W3200750802 cites W2588645351 @default.
- W3200750802 cites W2597062310 @default.
- W3200750802 cites W2610261021 @default.
- W3200750802 cites W2612868058 @default.
- W3200750802 cites W2614504158 @default.
- W3200750802 cites W2620653306 @default.
- W3200750802 cites W2623089849 @default.
- W3200750802 cites W2626291518 @default.
- W3200750802 cites W2715749014 @default.
- W3200750802 cites W2732346161 @default.
- W3200750802 cites W2735373986 @default.
- W3200750802 cites W2742501530 @default.
- W3200750802 cites W2745668487 @default.
- W3200750802 cites W2750602453 @default.
- W3200750802 cites W2751912349 @default.
- W3200750802 cites W2765195183 @default.
- W3200750802 cites W2776057754 @default.
- W3200750802 cites W2783500974 @default.
- W3200750802 cites W2783596779 @default.
- W3200750802 cites W2792338464 @default.
- W3200750802 cites W2797997996 @default.