Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200770491> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W3200770491 abstract "Abstract Background Clinically, Yiqi Dingxuan Yin promotes nerve function recovery and improves nerve function defect symptoms; however, the underlying molecular pathways remain unknown. In this study, we established a rat model of cerebral ischaemia induced by middle cerebral artery occlusion (MCAO). The effects of Yiqi Dingxuan Yin on the neurological function and local neuron morphology were compared with those of butylphthalide, which is used to treat ischemic stroke, and the possible mechanisms of action were explored. Methods Of 97 healthy adult male Sprague‒Dawley rats, 20 were randomly assigned to the sham operation group. The remaining rats underwent MCAO. Model generation was successful in 60 rats, which were randomly divided into a model group, butylphthalide group, and Yiqi Dingxuan Yin group (n = 20/group) administered distilled water, butylphthalide capsule, and Yiqi Dingxuan Yin, respectively. Zea-Longa scores were used to assess the neurological function of the rats at 1, 3, 7, and 14 days. Haematoxylin and eosin staining of brain sections was used to observe morphological changes in the rat hippocampus. Apoptosis of nerve cells was detected using TUNEL staining. The expression levels of erythropoietin/erythropoietin receptor (EPO/EPOR), vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor/tyrosine receptor kinase B (BDNF/TrkB) protein in the ischaemic brain tissue were detected using immunohistochemistry. Results The apoptosis rate, and EPO/EPOR, VEGF, and BDNF/TrkB expression levels were higher in the model group than in the sham operation group ( P < 0.05). Among MCAO groups, the nerve function deficit score and cell apoptosis rate were lower ( P < 0.05), whereas the EPO/EPOR, VEGF, and BDNF/TrkB protein expression levels were higher ( P < 0.05) in both the butylphthalide and Yiqi Dingxuan Yin groups than in the model group. Conclusions Yiqi Dingxuan Yin can improve the neural function and morphology of neurons after cerebral ischaemia injury in rats, with a more significant effect at 14 days. This may be related to the upregulation of EPO/EPOR, VEGF, and BDNF/TrkB protein expression, which may promote angiogenesis to improve cerebral blood flow and oxygen supply, thereby protecting the form and function of neurons and promoting the restoration of impaired neural function." @default.
- W3200770491 created "2021-09-27" @default.
- W3200770491 creator A5002884286 @default.
- W3200770491 creator A5024328555 @default.
- W3200770491 creator A5025161064 @default.
- W3200770491 creator A5041851671 @default.
- W3200770491 creator A5048279362 @default.
- W3200770491 creator A5063958289 @default.
- W3200770491 creator A5071276097 @default.
- W3200770491 creator A5076931316 @default.
- W3200770491 date "2021-09-13" @default.
- W3200770491 modified "2023-10-05" @default.
- W3200770491 title "Yiqi Dingxuan Yin improves cerebral ischaemic injury in rats by inhibiting apoptosis and promoting angiogenesis" @default.
- W3200770491 doi "https://doi.org/10.21203/rs.3.rs-885692/v1" @default.
- W3200770491 hasPublicationYear "2021" @default.
- W3200770491 type Work @default.
- W3200770491 sameAs 3200770491 @default.
- W3200770491 citedByCount "0" @default.
- W3200770491 crossrefType "posted-content" @default.
- W3200770491 hasAuthorship W3200770491A5002884286 @default.
- W3200770491 hasAuthorship W3200770491A5024328555 @default.
- W3200770491 hasAuthorship W3200770491A5025161064 @default.
- W3200770491 hasAuthorship W3200770491A5041851671 @default.
- W3200770491 hasAuthorship W3200770491A5048279362 @default.
- W3200770491 hasAuthorship W3200770491A5063958289 @default.
- W3200770491 hasAuthorship W3200770491A5071276097 @default.
- W3200770491 hasAuthorship W3200770491A5076931316 @default.
- W3200770491 hasBestOaLocation W32007704911 @default.
- W3200770491 hasConcept C126322002 @default.
- W3200770491 hasConcept C134018914 @default.
- W3200770491 hasConcept C160539049 @default.
- W3200770491 hasConcept C167734588 @default.
- W3200770491 hasConcept C170493617 @default.
- W3200770491 hasConcept C190283241 @default.
- W3200770491 hasConcept C196795494 @default.
- W3200770491 hasConcept C204232928 @default.
- W3200770491 hasConcept C25498285 @default.
- W3200770491 hasConcept C2777025900 @default.
- W3200770491 hasConcept C2778423431 @default.
- W3200770491 hasConcept C2778534260 @default.
- W3200770491 hasConcept C2780394083 @default.
- W3200770491 hasConcept C2781100881 @default.
- W3200770491 hasConcept C31102739 @default.
- W3200770491 hasConcept C42219234 @default.
- W3200770491 hasConcept C55493867 @default.
- W3200770491 hasConcept C71924100 @default.
- W3200770491 hasConcept C86803240 @default.
- W3200770491 hasConcept C97124661 @default.
- W3200770491 hasConceptScore W3200770491C126322002 @default.
- W3200770491 hasConceptScore W3200770491C134018914 @default.
- W3200770491 hasConceptScore W3200770491C160539049 @default.
- W3200770491 hasConceptScore W3200770491C167734588 @default.
- W3200770491 hasConceptScore W3200770491C170493617 @default.
- W3200770491 hasConceptScore W3200770491C190283241 @default.
- W3200770491 hasConceptScore W3200770491C196795494 @default.
- W3200770491 hasConceptScore W3200770491C204232928 @default.
- W3200770491 hasConceptScore W3200770491C25498285 @default.
- W3200770491 hasConceptScore W3200770491C2777025900 @default.
- W3200770491 hasConceptScore W3200770491C2778423431 @default.
- W3200770491 hasConceptScore W3200770491C2778534260 @default.
- W3200770491 hasConceptScore W3200770491C2780394083 @default.
- W3200770491 hasConceptScore W3200770491C2781100881 @default.
- W3200770491 hasConceptScore W3200770491C31102739 @default.
- W3200770491 hasConceptScore W3200770491C42219234 @default.
- W3200770491 hasConceptScore W3200770491C55493867 @default.
- W3200770491 hasConceptScore W3200770491C71924100 @default.
- W3200770491 hasConceptScore W3200770491C86803240 @default.
- W3200770491 hasConceptScore W3200770491C97124661 @default.
- W3200770491 hasLocation W32007704911 @default.
- W3200770491 hasOpenAccess W3200770491 @default.
- W3200770491 hasPrimaryLocation W32007704911 @default.
- W3200770491 hasRelatedWork W1811706535 @default.
- W3200770491 hasRelatedWork W1843826213 @default.
- W3200770491 hasRelatedWork W1996560509 @default.
- W3200770491 hasRelatedWork W1997652091 @default.
- W3200770491 hasRelatedWork W2032103118 @default.
- W3200770491 hasRelatedWork W2312318667 @default.
- W3200770491 hasRelatedWork W2362255877 @default.
- W3200770491 hasRelatedWork W2508956885 @default.
- W3200770491 hasRelatedWork W2523315004 @default.
- W3200770491 hasRelatedWork W3200770491 @default.
- W3200770491 isParatext "false" @default.
- W3200770491 isRetracted "false" @default.
- W3200770491 magId "3200770491" @default.
- W3200770491 workType "article" @default.