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• W3200803301 abstract "ABSTRACT Energy production and utilization is critically important for animal development and growth. How it is regulated in space and time during tissue growth remains largely unclear. Toward this end, we used a FRET-based adenosine triphosphate (ATP) sensor to dynamically monitor ATP levels across a growing tissue, using the Drosophila wing disc. We discovered that steady-state levels of ATP are spatially uniform across the wing pouch. Pharmacologically inhibiting oxidative phosphorylation, however, reveals spatial heterogeneities in metabolic behavior, whereby signaling centers at compartment boundaries produce more ATP from glycolysis than the rest of the tissue. Genetic perturbations indicate that the conserved Hedgehog (Hh) signaling pathway can enhance ATP production by glycolysis. Collectively, our work reveals a positive feedback loop between Hh signaling and energy metabolism, advancing our understanding of the connection between conserved developmental patterning genes and energy production during animal tissue development." @default.
• W3200803301 created "2021-09-27" @default.
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• W3200803301 date "2021-09-12" @default.
• W3200803301 modified "2023-10-16" @default.
• W3200803301 title "Hedgehog signaling can enhance glycolytic ATP production in the <i>Drosophila</i> wing disc" @default.
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• W3200803301 doi "https://doi.org/10.1101/2021.09.11.459911" @default.
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