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- W3200809111 abstract "The sphingolipids ceramide (Cer), ceramide-1-phosphate (C1P), sphingosine (Sph), and sphingosine-1-phosphate (S1P)) are key signaling molecules that regulate many patho-biological processes. During the last decade, they have gained increasing attention since they may participate in important and numerous retinal processes, such as neuronal survival and death, proliferation and migration of neuronal and vascular cells, inflammation, and neovascularization. Cer for instance has emerged as a key mediator of inflammation and death of neuronal and retinal pigment epithelium cells in experimental models of retinopathies such as glaucoma, age-related macular degeneration (AMD), and retinitis pigmentosa. S1P may have opposite biological actions, preventing photoreceptor and ganglion cell degeneration but also promoting inflammation, fibrosis, and neovascularization in AMD, glaucoma, and pro-fibrotic disorders. Alterations in Cer, S1P, and ceramide 1- phosphate may also contribute to uveitis. Furthermore, use of inhibitors that either prevent Cer increase or modulate S1P signaling, such as Myriocin, desipramine, and Fingolimod (FTY720), have been shown to preserve neuronal viability and retinal function. Collectively, the expanding role for these sphingolipids in the modulation of vital processes in retina cell types and in their dysregulation in retinal degenerations makes them attractive therapeutic targets." @default.
- W3200809111 created "2021-09-27" @default.
- W3200809111 creator A5010564331 @default.
- W3200809111 creator A5020300132 @default.
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- W3200809111 creator A5028818228 @default.
- W3200809111 creator A5037321999 @default.
- W3200809111 creator A5079821940 @default.
- W3200809111 date "2021-11-01" @default.
- W3200809111 modified "2023-09-26" @default.
- W3200809111 title "Updates on sphingolipids: Spotlight on retinopathy" @default.
- W3200809111 cites W1514747902 @default.
- W3200809111 cites W180812339 @default.
- W3200809111 cites W182664335 @default.
- W3200809111 cites W1915008606 @default.
- W3200809111 cites W1964788380 @default.
- W3200809111 cites W1966206121 @default.
- W3200809111 cites W1966573702 @default.
- W3200809111 cites W1967709839 @default.
- W3200809111 cites W1969869131 @default.
- W3200809111 cites W1972631980 @default.
- W3200809111 cites W1974151956 @default.
- W3200809111 cites W1974241505 @default.
- W3200809111 cites W1977141020 @default.
- W3200809111 cites W1982277787 @default.
- W3200809111 cites W1983755623 @default.
- W3200809111 cites W1983865931 @default.
- W3200809111 cites W1984142578 @default.
- W3200809111 cites W1984254677 @default.
- W3200809111 cites W1984738215 @default.
- W3200809111 cites W19857607 @default.
- W3200809111 cites W1990834174 @default.
- W3200809111 cites W1991429239 @default.
- W3200809111 cites W1991657227 @default.
- W3200809111 cites W1993968665 @default.
- W3200809111 cites W1994236211 @default.
- W3200809111 cites W1996605319 @default.
- W3200809111 cites W2000334999 @default.
- W3200809111 cites W2000673878 @default.
- W3200809111 cites W2008333628 @default.
- W3200809111 cites W2011918841 @default.
- W3200809111 cites W2014428666 @default.
- W3200809111 cites W2014941026 @default.
- W3200809111 cites W2016087648 @default.
- W3200809111 cites W2018622490 @default.
- W3200809111 cites W2021303092 @default.
- W3200809111 cites W2023750468 @default.
- W3200809111 cites W2025211623 @default.
- W3200809111 cites W2026898424 @default.
- W3200809111 cites W2028061763 @default.
- W3200809111 cites W2028440370 @default.
- W3200809111 cites W2032315776 @default.
- W3200809111 cites W2041581075 @default.
- W3200809111 cites W2041817852 @default.
- W3200809111 cites W2042538675 @default.
- W3200809111 cites W2043084962 @default.
- W3200809111 cites W2049350428 @default.
- W3200809111 cites W2050254589 @default.
- W3200809111 cites W2050389962 @default.
- W3200809111 cites W2050987891 @default.
- W3200809111 cites W2052702367 @default.
- W3200809111 cites W2053204073 @default.
- W3200809111 cites W2059712756 @default.
- W3200809111 cites W2062366330 @default.
- W3200809111 cites W2062376915 @default.
- W3200809111 cites W2065360214 @default.
- W3200809111 cites W2066594184 @default.
- W3200809111 cites W2067108500 @default.
- W3200809111 cites W2072716086 @default.
- W3200809111 cites W2074070290 @default.
- W3200809111 cites W2074214994 @default.
- W3200809111 cites W2075420402 @default.
- W3200809111 cites W2075713864 @default.
- W3200809111 cites W2077498400 @default.
- W3200809111 cites W2081997365 @default.
- W3200809111 cites W2082509428 @default.
- W3200809111 cites W2084432001 @default.
- W3200809111 cites W2086577757 @default.
- W3200809111 cites W2088941906 @default.
- W3200809111 cites W2089901083 @default.
- W3200809111 cites W2092670720 @default.
- W3200809111 cites W2108091182 @default.
- W3200809111 cites W2110251929 @default.
- W3200809111 cites W2110388058 @default.
- W3200809111 cites W2111032565 @default.
- W3200809111 cites W2112863102 @default.
- W3200809111 cites W2113081845 @default.
- W3200809111 cites W2119963394 @default.
- W3200809111 cites W2120478897 @default.
- W3200809111 cites W2120818428 @default.
- W3200809111 cites W2130226531 @default.
- W3200809111 cites W2133528282 @default.
- W3200809111 cites W2136540747 @default.
- W3200809111 cites W2139991488 @default.
- W3200809111 cites W2141368114 @default.
- W3200809111 cites W2142041241 @default.
- W3200809111 cites W2149528201 @default.
- W3200809111 cites W2151152045 @default.