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- W3200810111 abstract "Canine babesiosis is a tick-borne disease with a worldwide distribution, caused by the haemoprotozoan parasites of the genus Babesia . One of the most prevalent complication is acute kidney injury, and an early diagnosis of altered kidney function remains a challenge for veterinary practice. The aim of this study was to assess the urine metabolic profile from dogs with babesiosis and different degree of kidney function using untargeted and targeted MS-based metabolomics approaches. In this study, 22 dogs naturally infected with Babesia canis and 12 healthy dogs were included. Untargeted metabolomics approach identified 601 features with a differential abundance between the healthy group and groups of dogs with babesiosis and different level of kidney function, with 27 of them identified as a match to known standards; while targeted approach identified 17 metabolites with significantly different concentrations between the groups. A pattern of significantly altered metabolites referring to the inflammatory host response, oxidative stress, and energy metabolism modulation in babesiosis was presented. Our findings have demonstrated that kidney dysfunction accompanying canine babesiosis was associated with changes in amino acid metabolism, energy metabolism, fatty acid metabolism, and biochemical pathways such as urea cycle and ammonia detoxication. These findings will enable the inclusion of urinary markers for the detection and monitoring of renal damage in babesiosis, as well as in other similar diseases." @default.
- W3200810111 created "2021-09-27" @default.
- W3200810111 creator A5012309640 @default.
- W3200810111 creator A5017278208 @default.
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- W3200810111 creator A5053845451 @default.
- W3200810111 creator A5062261434 @default.
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- W3200810111 creator A5070830910 @default.
- W3200810111 creator A5071697016 @default.
- W3200810111 creator A5077304931 @default.
- W3200810111 date "2021-09-17" @default.
- W3200810111 modified "2023-10-14" @default.
- W3200810111 title "Combined Untargeted and Targeted Metabolomics Approaches Reveal Urinary Changes of Amino Acids and Energy Metabolism in Canine Babesiosis With Different Levels of Kidney Function" @default.
- W3200810111 cites W115935368 @default.
- W3200810111 cites W1502502156 @default.
- W3200810111 cites W157502360 @default.
- W3200810111 cites W1632233101 @default.
- W3200810111 cites W1821258231 @default.
- W3200810111 cites W1835869439 @default.
- W3200810111 cites W1964606317 @default.
- W3200810111 cites W1966851916 @default.
- W3200810111 cites W1968242068 @default.
- W3200810111 cites W1968430975 @default.
- W3200810111 cites W1971606140 @default.
- W3200810111 cites W1987964493 @default.
- W3200810111 cites W1988264716 @default.
- W3200810111 cites W1990065094 @default.
- W3200810111 cites W1991341227 @default.
- W3200810111 cites W1991916578 @default.
- W3200810111 cites W1993026974 @default.
- W3200810111 cites W1995881213 @default.
- W3200810111 cites W1997062226 @default.
- W3200810111 cites W2004440931 @default.
- W3200810111 cites W2006565594 @default.
- W3200810111 cites W2012324319 @default.
- W3200810111 cites W2018424479 @default.
- W3200810111 cites W2019273270 @default.
- W3200810111 cites W2019940748 @default.
- W3200810111 cites W2027177947 @default.
- W3200810111 cites W2028621708 @default.
- W3200810111 cites W2030733339 @default.
- W3200810111 cites W2037677674 @default.
- W3200810111 cites W2042059142 @default.
- W3200810111 cites W2050885954 @default.
- W3200810111 cites W2053127406 @default.
- W3200810111 cites W2053835433 @default.
- W3200810111 cites W2053946842 @default.
- W3200810111 cites W2055212902 @default.
- W3200810111 cites W2056357493 @default.
- W3200810111 cites W2058731742 @default.
- W3200810111 cites W2069136915 @default.
- W3200810111 cites W2069430628 @default.
- W3200810111 cites W2091453021 @default.
- W3200810111 cites W2093703769 @default.
- W3200810111 cites W2095474836 @default.
- W3200810111 cites W2103145251 @default.
- W3200810111 cites W2103631176 @default.
- W3200810111 cites W2104996434 @default.
- W3200810111 cites W2109021692 @default.
- W3200810111 cites W2109163588 @default.
- W3200810111 cites W2110758916 @default.
- W3200810111 cites W2110933582 @default.
- W3200810111 cites W2111131756 @default.
- W3200810111 cites W2113468729 @default.
- W3200810111 cites W2120171195 @default.
- W3200810111 cites W2123674181 @default.
- W3200810111 cites W2123892334 @default.
- W3200810111 cites W2133541113 @default.
- W3200810111 cites W2138935646 @default.
- W3200810111 cites W2141128375 @default.
- W3200810111 cites W2143489383 @default.
- W3200810111 cites W2146779833 @default.
- W3200810111 cites W2147259528 @default.
- W3200810111 cites W2148141193 @default.
- W3200810111 cites W2165615844 @default.
- W3200810111 cites W2168811983 @default.
- W3200810111 cites W2168910111 @default.
- W3200810111 cites W2170565523 @default.
- W3200810111 cites W218896215 @default.
- W3200810111 cites W2296678584 @default.
- W3200810111 cites W2321312284 @default.
- W3200810111 cites W2409907949 @default.
- W3200810111 cites W2419604885 @default.
- W3200810111 cites W2512475397 @default.
- W3200810111 cites W2519730045 @default.
- W3200810111 cites W2576580888 @default.
- W3200810111 cites W2606546819 @default.
- W3200810111 cites W2608437019 @default.
- W3200810111 cites W2618565934 @default.
- W3200810111 cites W2749045202 @default.
- W3200810111 cites W2763615699 @default.
- W3200810111 cites W2765548225 @default.
- W3200810111 cites W2770957231 @default.
- W3200810111 cites W2771175433 @default.
- W3200810111 cites W2782262703 @default.
- W3200810111 cites W2788103046 @default.
- W3200810111 cites W2796109677 @default.
- W3200810111 cites W2839200018 @default.
- W3200810111 cites W2884894019 @default.