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• W3200811410 abstract "Residues spanning distinct regions of the low-complexity domain of the RNA-binding protein, Fused in Sarcoma (FUS-LC), form fibril structures with different core morphologies. Solid-state NMR experiments show that the 214-residue FUS-LC forms a fibril with an S-bend (core-1, residues 39-95), while the rest of the protein is disordered. In contrast, the fibrils of the C-terminal variant (FUS-LC-C; residues 111-214) have a U-bend topology (core-2, residues 112-150). Absence of the U-bend in FUS-LC implies that the two fibril cores do not coexist. Computer simulations show that these perplexing findings could be understood in terms of the population of sparsely populated fibril-like excited states in the monomer. The propensity to form core-1 is higher compared to core-2. We predict that core-2 forms only in truncated variants that do not contain the core-1 sequence. At the monomer level, sequence-dependent enthalpic effects determine the relative stabilities of the core-1 and core-2 topologies." @default.
• W3200811410 created "2021-09-27" @default.
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• W3200811410 date "2021-09-13" @default.
• W3200811410 modified "2023-10-12" @default.
• W3200811410 title "Sequence Determines the Switch in the Fibril Forming Regions in the Low-Complexity FUS Protein and Its Variants" @default.
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• W3200811410 doi "https://doi.org/10.1021/acs.jpclett.1c02310" @default.
• W3200811410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34516126" @default.
• W3200811410 hasPublicationYear "2021" @default.
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