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• W3200854328 abstract "Embryonic genome activation is a critical event in embryo development, in which the transcriptional program of the embryo is initiated. The timing and regulation of this process are species-specific. In vitro embryo production is becoming an important clinical and research tool in the horse; however, very little is known about genome activation in this species. The objective of this work was to identify the timing of genome activation, and the transcriptional networks involved, in in vitro-produced horse embryos. RNA-Seq was performed on oocytes and embryos at eight stages of development (MII, zygote, 2-cell, 4-cell, 8-cell, 16-cell, morula, blastocyst; n = 6 per stage, 2 from each of 3 mares). Transcription of seven genes was initiated at the 2-cell stage. The first substantial increase in gene expression occurred at the 4-cell stage (minor activation), followed by massive gene upregulation and downregulation at the 8-cell stage (major activation). An increase in intronic nucleotides, indicative of transcription initiation, was also observed at the 4-cell stage. Co-expression network analyses identified groups of genes that appeared to be regulated by common mechanisms. Investigation of hub genes and binding motifs enriched in the promoters of co-expressed genes implicated several transcription factors. This work represents, to the best of our knowledge, the first genomic evaluation of embryonic genome activation in horse embryos." @default.
• W3200854328 created "2021-09-27" @default.
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• W3200854328 date "2021-09-13" @default.
• W3200854328 modified "2023-09-27" @default.
• W3200854328 title "Genome activation in equine in vitro-produced embryos" @default.
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• W3200854328 doi "https://doi.org/10.1093/biolre/ioab173" @default.
• W3200854328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34515744" @default.
• W3200854328 hasPublicationYear "2021" @default.
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